1.52006
Chromolith® RP-18 endcapped (monolithic) HPLC Columns
L × I.D. 100 mm x 2 mm HPLC Column
Synonym(s):
Chromolith® Performance RP-18 endcapped 100-2 HPLC column
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Select a Size
About This Item
Recommended Products
Product Name
Chromolith® RP-18 endcapped, L × I.D. 100 mm x 2 mm HPLC column
material
PEEK column
Quality Level
Agency
suitable for USP L1
product line
Chromolith®
feature
endcapped
packaging
1 ea of
extent of labeling
18% Carbon loading
parameter
200 bar pressure
45 °C max. temp.
technique(s)
HPLC: suitable
LC/MS: suitable
UHPLC-MS: suitable
UHPLC: suitable
mass spectrometry (MS): suitable (High)
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Related Categories
1 of 4
This Item | 152001 | 102129 | 152007 |
|---|---|---|---|
| matrix active group C18 bonding phase | matrix active group C18 bonding phase | matrix active group C18 bonding phase | matrix active group C18 bonding phase |
| matrix monolithic silica | matrix monolithic silica | matrix monolithic silica | matrix monolithic silica |
| product line Chromolith® | product line Chromolith® | product line Chromolith® | product line Chromolith® |
| technique(s) HPLC: suitable, UHPLC-MS: suitable, mass spectrometry (MS): suitable (High), LC/MS: suitable, UHPLC: suitable | technique(s) HPLC: suitable, LC/MS: suitable, mass spectrometry (MS): suitable (High) | technique(s) HPLC: suitable, LC/MS: suitable, mass spectrometry (MS): suitable (High) | technique(s) LC/MS: suitable, UHPLC-MS: suitable, UHPLC: suitable, mass spectrometry (MS): suitable (High) |
| pore size 1.5 μm macroporosity, 13 nm mesoporosity | pore size 13 nm mesoporosity, 2 μm macroporosity | pore size 13 nm mesoporosity, 2 μm macroporosity | pore size 1.5 μm macroporosity, 13 nm mesoporosity |
General description
Chromolith® Performance RP-18 endcapped 100-2 columns have macropores with 1.5 μm diameter, giving a column efficiency exceeding 100,000 plates/meter. The mesopores are 13 nm (130 Å), the surface modification is octadecylsilane with full end-capping. Chromolith® Performance RP-18 endcapped 100-2 columns fall under the USP L1 Classification. The column efficiency is comparable to a 3-4 μm particle size fully porous particulate column. Chromolith® Performance RP-18 endcapped 100-2 columns are perfectly suitable for LC-MS applications.
The column dimension of 100 mm length and 2 mm I.D. is the best choice for fast separations of complex samples on any U/HPLC System.
The revolutionary, monolithic silica with its unique combination of macropores and mesopores enables:
—Rapid separations at very low column back-pressure
—High matrix tolerance, allowing time and cost savings with simplified workflows
—Cost-savings due to extended column lifetimes
—Connection of columns, flow gradients and the use of mobile phases with higher viscosity
The recommended Guard-columns are:
Chromolith® RP-18 endcapped 5-2 guard cartridges (3 pieces) [1.52009] with the Chromolith® Guard Cartridge Holder (kit) 5 mm x 2 mm [1.52004]
The Chromolith® column coupler can be used to significantly increase the separation efficiency of Chromolith® columns by coupling several columns in series (up to 100,000 plates/per column). [1.51467]
Learn more:
Brochure: Race through your Separations on Any System. Chromolith® Monolithic Silica HPLC Columns
All Supelco HPLC Columns, including monolithic Chromolith® columns, are fully compatible to all HPLC and UHPLC Instruments.
Supelco HPLC Products: The Best Choice for Any LC Instrument
Application
- Rapid Determination of 30 Polyphenols in Tongmai Formula: This study utilized the Chromolith® RP-18 endcapped column in a liquid chromatography-tandem mass spectrometry setup to analyze 30 polyphenolic compounds in a traditional Chinese medicine formula, demonstrating its application in pharmaceutical analysis and quality control of complex herbal formulations (Wang et al., 2017).
- Ultra-fast gradient LC method for omeprazole analysis using a monolithic column: The Chromolith® RP-18 endcapped column was employed in an ultra-fast gradient liquid chromatography method for the analysis of omeprazole in enteric-coated pellets, highlighting its efficiency in pharmaceutical quality control and rapid method development (Borges et al., 2010).
Analysis Note
Pressure: ≤ 55 bar
Performance (anthracene)
Theoretical Plates (N/m) (Anthracene): ≥ 100000
Capacity factor (Anthracene): 3.9 - 4.6
Tailing (USP): 0.90 - 1.30 %
Selectivity
separation factor (anthracene/progesterone): 2.30 - 2.60
Legal Information
Certificates of Analysis (COA)
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Articles
Monolithic silica HPLC columns enable high-throughput analysis at low back pressure without loss of separation efficiency or peak capacity.
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