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850365P

Avanti

18:0 PC (DSPC)

Name: 18:0 PC (DSPC)
Brand: AVANTI

Avanti Polar Lipids

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Synonym(s):

1,2-dioctadecanoyl-sn-glycero-3-phosphocholine; DSPC; PC(18:0/18:0)

Empirical Formula (Hill Notation):

C₄₄H₈₈NO₈P

CAS Number:

816-94-4

Molecular Weight:

790.15

UNSPSC Code:

51191904

NACRES:

NA.25

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Sigma-Aldrich

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description

1,2-distearoyl-sn-glycero-3-phosphocholine

Assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 1 g (850365P-1G)
pkg of 1 × 200 mg (850365P-200MG)
pkg of 1 × 25 mg (850365P-25MG)
pkg of 1 × 500 mg (850365P-500MG)

manufacturer/tradename

Avanti Polar Lipids

application(s)

advanced drug delivery

lipid type

phospholipids
cardiolipins

shipped in

dry ice

storage temp.

−20°C

SMILES string

[O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O)=O

InChI

1S/C44H88NO8P/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-36-43(46)50-40-42(41-52-54(48,49)51-39-38-45(3,4)5)53-44(47)37-35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-2/h42H,6-41H2,1-5H3/t42-/m1/s1

InChI key

NRJAVPSFFCBXDT-HUESYALOSA-N

General description

1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC) is a phospholtidylcholine with alkyl chain comprising 18 carbons. It has phophatidylcholine head group and its structure is similar to 1,2-dipalmitoyl-sn-glycero-3-phosphatidylcholine (DPPC).

The list of Phosphatidylcholine products offered by Avanti is designed to provide compounds having a variety of physical properties. Products available include short chain (C3-C8 are water soluble and hygroscopic), saturated, multi-unsaturated and mixed acid PC′s. All of the products are purified by HPLC, and special precautions are taken to protect the products for oxidization and hydrolysis.

Application

18:0 PC (DSPC) has been used:

in the microbubble monolayer preparation for biomolecule delivery studies into protoplasts
in the preparation of liposomes for immobilization studies
in the generation of porphyrin-phospholipid (PoP) liposomes for irinotecan (IRT) and doxorubicin delivery

Biochem/physiol Actions

1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC) is used in combination with other members of phosphatidylcholine for the generation of mixed bilayer system. It is majorly used in conventional and stealth liposome preparation for drug delivery studies.

Packaging

20 mL Clear Glass Screw Cap Vial (850365P-1G)

20 mL Clear Glass Screw Cap Vial (850365P-500MG)

5 mL Amber Glass Screw Cap Vial (850365P-200MG)

5 mL Amber Glass Screw Cap Vial (850365P-25MG)

also commonly purchased with this product

Product No.

Description

Pricing

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Comparative study of PEGylated and conventional liposomes as carriers for shikonin

Tsermentseli S, et al.

Fluids, 3(2), 36-36 (2018)

Interaction of polyphenols with model membranes: Putative implications to mouthfeel perception.

Ana Reis et al.

Biochimica et biophysica acta. Biomembranes, 1862(2), 183133-183133 (2019-12-01)

Food polyphenols in fruits juices, tea, coffee, wine and beer confer sensory properties such as colour, astringency and bitterness. The development of functional healthy drinks without the unpleasant sensory feeling is boosting research for a clearer understanding on the interactions

Investigating the structure of multicomponent gel-phase lipid bilayers

Hartkamp R, et al.

Biophysical Journal, 111(4), 813-823 (2016)

Pharmacological Characterization of a Novel ENaCα siRNA (GSK2225745) With Potential for the Treatment of Cystic Fibrosis.

Kenneth L Clark et al.

Molecular therapy. Nucleic acids, 2, e65-e65 (2013-01-17)

Lung pathology in cystic fibrosis is linked to dehydration of the airways epithelial surface which in part results from inappropriately raised sodium reabsorption through the epithelial sodium channel (ENaC). To identify a small-interfering RNA (siRNA) which selectively inhibits ENaC expression

Biomolecule delivery into canola protoplasts by centrifuging cells with microbubbles

He C, et al.

Febs Letters, 587(3), 285-290 (2013)

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Documents

18:0 PC (DSPC)

Avanti Polar Lipids

Recommended Products

Properties

description

Assay

form

packaging

manufacturer/tradename

application(s)

lipid type

shipped in

storage temp.

SMILES string

InChI

InChI key

Description

General description

Application

Biochem/physiol Actions

Packaging

Related Products

also commonly purchased with this product

Safety Information

WGK

Flash Point(F)

Flash Point(C)

Documentation

Certificates of Analysis (COA)

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Peer Reviewed Papers

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