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QBD10512

Sigma-Aldrich

Azido-dPEG®8-acid

Synonym(s):

Polyethylene glycol

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About This Item

Empirical Formula (Hill Notation):
C19H37N3O10
CAS Number:
1214319-92-2
Molecular Weight:
467.51
MDL number:
MFCD21363300
UNSPSC Code:
12352106
PubChem Substance ID:
329823934
NACRES:
NA.22

Assay

>90%

form

solid or viscous liquid

reaction suitability

reaction type: click chemistry
reagent type: cross-linking reagent
reaction type: click chemistry

functional group

azide
carboxylic acid

polymer architecture

shape: linear
functionality: heterobifunctional

shipped in

ambient

storage temp.

−20°C

SMILES string

OC(CCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])=O

Related Categories

Features and Benefits

The azido-dPEG®8 contains an azide function on one end of a single molecular weight dPEG® spacer (32.2Å) and a reactive group on the other end of the spacer. The dPEG® spacer is hydrophilic and non-immunogenic and improves the water solubility of the target molecule while reducing the immunogenicity and increasing the hydrodynamic volume of the target. The reactive acid functional group may be activated with 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) or N,N′-dicyclohexylcarbodiimide (DCC) for conjugation to an amine. The azide group reacts with an alkyne in the well-known click chemistry reaction. The click chemistry reaction proceeds by copper(I) or ruthenium catalysis or in a strain-catalyzed reaction with certain types of alkyne partners.

Legal Information

Products Protected under U.S. Patents # 7,888,536 B2
dPEG is a registered trademark of Quanta BioDesign

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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