D125407
DIC
99%, for peptide synthesis
Synonym(s):
N,N′-Diisopropylcarbodiimide
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About This Item
Linear Formula:
(CH3)2CHN=C=NCH(CH3)2
CAS Number:
Molecular Weight:
126.20
Beilstein:
878281
EC Number:
MDL number:
UNSPSC Code:
12352111
PubChem Substance ID:
NACRES:
NA.22
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Product Name
DIC, 99%
Assay
99%
form
liquid
reaction suitability
reaction type: Coupling Reactions
refractive index
n20/D 1.433 (lit.)
bp
145-148 °C (lit.)
density
0.815 g/mL at 20 °C (lit.)
application(s)
peptide synthesis
SMILES string
CC(C)N=C=NC(C)C
InChI
1S/C7H14N2/c1-6(2)8-5-9-7(3)4/h6-7H,1-4H3
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General description
DIC is an abbreviated form of N,N′-diisopropylcarbodiimide. It plays a role in the cyclization of N-(β-hydroxy)amides to form 2-oxazolines.
Application
Alternative to dicyclohexylcarbodiimide in peptide synthesis.
Coupling reagent for peptide syntheses.
DIC (N,N′-Diisopropylcarbodiimide) has been used in combination with 1-hydroxy-7-azabenzotriazole (HOAt) for the coupling of amino acid with N-allylglycine to form N-allylpeptide.
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Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 1 Inhalation - Eye Dam. 1 - Flam. Liq. 3 - Resp. Sens. 1 - Skin Sens. 1
Storage Class Code
3 - Flammable liquids
WGK
WGK 3
Flash Point(F)
91.4 °F
Flash Point(C)
33 °C
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
非剧毒-急性毒性1
危险化学品
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Collection of Czechoslovak Chemical Communications, 59, 691-691 (1994)
Tetrahedron Letters, 35, 5981-5981 (1994)
Cody L Gilleland et al.
Genetics, 201(1), 39-46 (2015-07-15)
A major goal in the study of human diseases is to assign functions to genes or genetic variants. The model organism Caenorhabditis elegans provides a powerful tool because homologs of many human genes are identifiable, and large collections of genetic
Synthesis of 2-oxazolines mediated by N,N'-diisopropylcarbodiimide.
Crosignani S, et al.
Tetrahedron Letters, 45(52), 9611-9615 (2004)
P J Weber et al.
Bioorganic & medicinal chemistry letters, 8(6), 597-600 (1999-01-01)
A new method has been developed to synthesize fluorescein labeled peptides, compounds of increasing importance in bioorganic chemistry, cell biology, pharmacology, drug targeting and medicinal chemistry. We show, that 4(5)-carboxyfluorescein is much more efficient than the hitherto predominantly utilized reagents
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