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D125407

Sigma-Aldrich

DIC

99%, for peptide synthesis

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Synonym(s):
N,N′-Diisopropylcarbodiimide
Linear Formula:
(CH3)2CHN=C=NCH(CH3)2
CAS Number:
693-13-0
Molecular Weight:
126.20
Beilstein:
878281
EC Number:
211-743-7
MDL number:
MFCD00065689
UNSPSC Code:
12352111
PubChem Substance ID:
57654069
NACRES:
NA.22

Quality Level

200

Assay

99%

form

liquid

reaction suitability

reaction type: Coupling Reactions

refractive index

n20/D 1.433 (lit.)

bp

145-148 °C (lit.)

density

0.815 g/mL at 20 °C (lit.)

application(s)

peptide synthesis

SMILES string

CC(C)N=C=NC(C)C

InChI

1S/C7H14N2/c1-6(2)8-5-9-7(3)4/h6-7H,1-4H3

InChI key

BDNKZNFMNDZQMI-UHFFFAOYSA-N

Gene Information

human ... EPHX2(2053)
mouse ... Ephx2(13850)

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General description

DIC is an abbreviated form of N,N′-diisopropylcarbodiimide. It plays a role in the cyclization of N-(β-hydroxy)amides to form 2-oxazolines.

Application

Coupling reagent for peptide syntheses.
DIC (N,N′-Diisopropylcarbodiimide) has been used in combination with 1-hydroxy-7-azabenzotriazole (HOAt) for the coupling of amino acid with N-allylglycine to form N-allylpeptide.
Alternative to dicyclohexylcarbodiimide in peptide synthesis.

related product

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Description
Pricing

Signal Word

Danger

Hazard Statements

H226,H317,H318,H330,H334

Hazard Classifications

Acute Tox. 1 Inhalation - Eye Dam. 1 - Flam. Liq. 3 - Resp. Sens. 1 - Skin Sens. 1

WGK

WGK 3

Flash Point(F)

91.4 °F

Flash Point(C)

33 °C

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

非剧毒-急性毒性1
危险化学品

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Tetrahedron Letters, 35, 5981-5981 (1994)
Collection of Czechoslovak Chemical Communications, 59, 691-691 (1994)
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