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Key Documents

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Safety Information

A71328

Sigma-Aldrich

4-Aminophenol

≥98%

Synonym(s):

4-Hydroxyaniline

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¥301.37
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¥478.72
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¥1,937.50

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5 G
¥301.37
25 G
¥478.72
100 G
¥1,937.50

About This Item

Linear Formula:
H2NC6H4OH
CAS Number:
123-30-8
Molecular Weight:
109.13
Beilstein:
385836
EC Number:
204-616-2
MDL number:
MFCD00007869
UNSPSC Code:
12352100
PubChem Substance ID:
24891177
NACRES:
NA.22

¥301.37

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Quality Level

200

Assay

≥98%

form

granular
powder or crystals

mp

185-189 °C (lit.)

solubility

water: slightly soluble

SMILES string

Nc1ccc(O)cc1

InChI

1S/C6H7NO/c7-5-1-3-6(8)4-2-5/h1-4,8H,7H2

InChI key

PLIKAWJENQZMHA-UHFFFAOYSA-N

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This Item
299693638560843951
Adipoyl chloride 98%

165212

Adipoyl chloride

Azelaic acid dichloride 98%

299693

Azelaic acid dichloride

Methyl adipoyl chloride 97%

638560

Methyl adipoyl chloride

Adipyl chloride for synthesis

843951

Adipyl chloride

assay

98%

assay

98%

assay

97%

assay

-

density

1.259 g/mL at 25 °C (lit.)

density

1.143 g/mL at 25 °C (lit.)

density

1.148 g/mL at 25 °C (lit.)

density

1.259 g/cm3 at 25 °C

form

liquid

form

liquid

form

-

form

liquid

refractive index

n20/D 1.471 (lit.)

refractive index

n20/D 1.467 (lit.)

refractive index

n20/D 1.4470 (lit.)

refractive index

-

bp

105-107 °C/2 mmHg (lit.)

bp

166 °C/18 mmHg (lit.)

bp

76 °C/0.8 mmHg (lit.)

bp

-

Quality Level

200

Quality Level

200

Quality Level

100

Quality Level

200

General description

4-Aminophenol (4-Hydroxyaniline) is an organic building block. Its quantification in water samples upto the detection limit of 8×10-10mol l-1 has been proposed by employing single-wall carbon nanotubes (SWNT)-nafion film coated glassy carbon electrodes.[1] It is present as the main contaminant in pharmaceutical formulations of paracetamol. High-performance liquid chromatographic (HPLC) method with amperometric detection has been reported for its determination in various analgesic formulations.[2] It has been reported to be formed from the reduction of 4-nitrophenol (Nip) under metal-free conditions catalyzed by N-doped graphene (NG).[3]

Application

4-Aminophenol is suitable for use in the synthesis of 2,2-bis(4-aminophenoxy) benzonitrile [4-APBN], a monomer required for the preparation of series of polyamides and poly(amide-imide)s.[4] It may be used as derivatization reagent to improve the ionization of aliphatic and aromatic aldehydes by paper spray ionization mass spectrometry.[5]

Signal Word

Warning

Hazard Classifications

Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Muta. 2 - Skin Sens. 1 - STOT RE 2

Target Organs

Kidney

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

危险化学品
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    Certificates of Analysis (COA)

    Lot/Batch Number
    STBG7989
    BCCL4614
    BCCK0323
    BCCJ8628
    BCCH2332

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    Metal-free catalytic reduction of 4-nitrophenol to 4-aminophenol by N-doped graphene.
    Kong XK, et al.
    Energy & Environmental Science, 6(11), 3260-3266 (2013)
    Saxena A, et al.
    Eur. Polymer J., 39(2), 401-405 (2003)
    E Wyszecka-Kaszuba et al.
    Journal of pharmaceutical and biomedical analysis, 32(4-5), 1081-1086 (2003-08-06)
    A method for the determination of 4-aminophenol, the main impurity of paracetamol, by high-performance liquid chromatographic (HPLC) method with amperometric detection has been developed. The analysis was performed in an isocratic mode on a reversed phase Luna column 5 microm
    Wensheng Huang et al.
    Talanta, 61(3), 411-416 (2008-10-31)
    A single-wall carbon nanotubes (SWNT)-Nafion film coated glassy carbon electrode (GCE) was described for the determination of 4-aminophenol. In pH 3.0 sodium citrate-HCl buffer, the oxidation peak current of 4-aminophenol increases greatly at the SWNT-Nafion film coated GCE in contrast
    E P Gil et al.
    Clinical chemistry, 36(4), 662-665 (1990-04-01)
    A competitive enzyme-linked immunoabsorbent assay based on the flow-injection amperometric detection of p-aminophenol has been investigated with use of the materials and general procedure of a commercial kit for the determination of theophylline in human serum. The antibody is immobilized
    View All Related Papers

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