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Key Documents

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909866

Sigma-Aldrich

Poly(2-(dimethylamino)ethyl methacrylate)

average Mn 10,000

Synonym(s):

Hydrophilic polymer, PDMAEMA, pH sensitive, pH-responsive

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500 MG
CN¥939.75
1 G
CN¥1,618.37

CN¥939.75

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500 MG
CN¥939.75
1 G
CN¥1,618.37

About This Item

Linear Formula:
(C8H15NO2)n
UNSPSC Code:
12162002
NACRES:
NA.23

CN¥939.75

Please contact Customer Service for Availability
Request a Bulk Order

form

powder or solid

mol wt

average Mn 10,000 (by GPC)
average Mn 10,000

color

white to faint yellow

PDI

≤1.4 (by GPC)

storage temp.

2-8°C

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This Item
100536429767V900614
4-氨基苯甲酸 ReagentPlus®, ≥99%

A9878

4-氨基苯甲酸

4-氨基苯甲酸 ReagentPlus®, 99%

100536

4-氨基苯甲酸

4-氨基苯甲酸 purified by sublimation, ≥99%

429767

4-氨基苯甲酸

4-氨基苯甲酸 Vetec™, reagent grade, 98%

V900614

4-氨基苯甲酸

assay

≥99%

assay

99%

assay

≥99%

assay

98%

product line

ReagentPlus®

product line

ReagentPlus®

product line

-

product line

Vetec™

storage temp.

2-8°C

storage temp.

-

storage temp.

-

storage temp.

-

solubility

ethanol: 50 mg/mL, clear, colorless to faintly yellow

solubility

95% ethanol: soluble 5%, clear to slightly hazy, colorless to yellow

solubility

-

solubility

-

mp

187-189 °C (lit.)

mp

187-189 °C (lit.)

mp

187-189 °C (lit.)

mp

187-189 °C (lit.)

Application

Poly(2-(dimethylamino)ethyl methacrylate) is a pH-responsive polymer. pH-responsive polymers are a group of stimuli-responsive polymers that can respond to solution pH by undergoing structural and property changes such as surface activity, chain conformation, solubility, and configuration. The term “pH-responsive polymers” is commonly used to describe polymers having ionisable acidic or basic residues whose ionization depends on solution pH. The physical properties of the polymer, such as its chain conformation, configuration, and solubility, can be tailored by manipulating the pH or ionic strength. These unique properties of pH responsive polymer systems consequently make them very useful in various applications such as drug delivery, gene delivery, sensors, surfaces, membranes, and chromatography.
pH-sensitive polymer systems combined with nanotechnology could be utilized as an alternative strategy to traditional targeting systems to overcome major problems in current chemotherapy represented by non-specific tissue distribution of the drugs, tumor heterogeneity, and multidrug resistance (MDR) against anticancer drugs.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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    Certificates of Analysis (COA)

    Lot/Batch Number
    MKCT1061
    MKCL5798

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    pH-sensitive polymers for drug delivery
    Huh K M,et al.
    Macromolecular Research, 20(3), 224?233-224?233 (2012)
    pH-Responsive polymers
    Kocak G , et al.
    Polym. Chem., 8, 144?176-144?176 (2017)
    Prithankar Pramanik et al.
    Macromolecular rapid communications, 37(18), 1499-1506 (2016-07-23)
    The synthesis, micellar aggregation, and pH-triggered intracellular drug delivery ability of an amphiphilic statistical copolymer (P2) are studied. Two methacrylate derivatives, one containing a hydrophilic pendant and the other containing a hydrophobic pendant chain, are copolymerized to produce P2. The
    Themis R Kyriakides et al.
    Journal of controlled release : official journal of the Controlled Release Society, 78(1-3), 295-303 (2002-01-05)
    Cytosolic delivery from endosomes is critical for those drugs that are susceptible to attack by lysosomal enzymes, such as DNA, RNA, oligonucleotides, proteins and peptides. Therefore, we have designed pH-sensitive, membrane-disruptive polymers to enhance the release of drugs from the
    Girish Kumar Tripathi et al.
    Current drug delivery, 8(6), 667-677 (2012-02-09)
    Helicobacter pylori reside in the gastric mucus layer and at the mucus-epithelial cell interface wherein access of antimicrobial drug to the infection site is restricted both from the stomach and from the gastric blood supply. The aim of the present
    View All Related Papers

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