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902241

Sigma-Aldrich

N-Hydroxysuccinimide poly(ethylene glycol)-block-poly(lactide-co-glycolide)

PEG average Mn 5000, PLGA average Mn 15000, lactide:glycolide 50:50

Synonym(s):

NHS-PEG-b-PLGA, NHS-PEG-PLGA

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5 ML
CN¥1,818.53
25 ML
CN¥4,521.32
100 ML
CN¥13,875.21
500 ML
CN¥58,467.54

CN¥1,818.53

Available to ship onApril 14, 2025Details

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5 ML
CN¥1,818.53
25 ML
CN¥4,521.32
100 ML
CN¥13,875.21
500 ML
CN¥58,467.54

About This Item

Linear Formula:
C10H14O5NS(C2H4O)nC2H4O[(C2H2O2)x(C3H4O2)y]mH
UNSPSC Code:
12352111
NACRES:
NA.23

CN¥1,818.53

Available to ship onApril 14, 2025Details

Request a Bulk Order

form

powder

feed ratio

lactide:glycolide 50:50
lactide:glycolide 50:50±5

mol wt

PEG Mn 4000-6000 g/mol (by NMR)
PEG average Mn 5000
PLGA Mn 13500-16500 g/mol (by NMR)
PLGA average Mn 15000

color

white

suitability

conforms to structure for NMR

storage temp.

−20°C

Related Categories

Application

N-Hydroxysuccinimide poly(ethylene glycol)-block-poly(lactide-co-glycolide) is a N-hydroxysuccinimide (NHS)-functionalized, biocompatible, amphiphilic block copolymer. Due to its self-assembling properties, this material can be used in the formation of nanoparticles for drug delivery. Additionally, due to the NHS-functionalization of the PEG block, this material can be used to rapidly covalently conjugate biomolecules, API, or targeting ligands. Potential uses include the targeted and/or controlled release of cancer drugs, anti-inflammatory drugs, antibiotics, or anesthetic agents.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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    Biodegradable PLGA-b-PEG polymeric nanoparticles: synthesis, properties and nanomedical applications as drug delivery system
    Locatelli, E. et al.
    Journal of Nanoparticle Research, 14, 1316-1316 (2012)
    Ilaria Monaco et al.
    Journal of medicinal chemistry, 60(10), 4510-4516 (2017-05-05)
    Polymeric nanoparticles (PNPs) may efficiently deliver in vivo therapeutics to tumors when conjugated to specific targeting agents. Gint4.T aptamer specifically recognizes platelet-derived growth factor receptor β and can cross the blood-brain barrier (BBB). We synthesized Gint4.T-conjugated PNPs able of high
    Yihan Xu et al.
    Journal of biomedical materials research. Part B, Applied biomaterials, 105(6), 1692-1716 (2016-04-22)
    Poly (lactic-co-glycolic acid) (PLGA) copolymers have been broadly used in controlled drug release applications. Because these polymers are biodegradable, they provide an attractive option for drug delivery vehicles. There are a variety of material, processing, and physiological factors that impact

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