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777366

Sigma-Aldrich

DBCO-Cy3

for Copper-free Click Chemistry

Synonym(s):

ADIBO-Cy3, Azadibenzocyclooctyne-Cy3, Dibenzocyclooctyne-Cy3

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1 MG
CN¥1,438.06
5 MG
CN¥3,959.18

CN¥1,438.06

Available to ship onApril 07, 2025Details

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1 MG
CN¥1,438.06
5 MG
CN¥3,959.18

About This Item

Empirical Formula (Hill Notation):
C62H84N6O11S3
Molecular Weight:
1185.56
UNSPSC Code:
12352200
PubChem Substance ID:
329767902
NACRES:
NA.22

CN¥1,438.06

Available to ship onApril 07, 2025Details

Request a Bulk Order

Quality Level

100

form

solid

reaction suitability

reaction type: click chemistry

storage temp.

−20°C

SMILES string

CC1(C)C(/C=C/C=C2N(CCCS([O-])(=O)=O)C3=CC=C(S(=O)([O-])=O)C=C3C/2(C)C)=[N+](CCCCCC(NCCC(N4CC(C=CC=C5)=C5C#CC6=C4C=CC=C6)=O)=O)C7=C1C=C(S(=O)([O-])=O)C=C7.CC[NH+](CC)CC.CC[NH+](CC)CC

InChI

1S/C50H54N4O11S3.2C6H15N/c1-49(2)40-32-38(67(60,61)62)23-25-43(40)52(45(49)18-12-19-46-50(3,4)41-33-39(68(63,64)65)24-26-44(41)53(46)30-13-31-66(57,58)59)29-11-5-6-20-47(55)51-28-27-48(56)54-34-37-16-8-7-14-35(37)21-22-36-15-9-10-17-42(36)54;2*1-4-7(5-2)6-3/h7-10,12,14-19,23-26,32-33H,5-6,11,13,20,27-31,34H2,1-4H3,(H3-,51,55,57,58,59,60,61,62,63,64,65);2*4-6H2,1-3H3

InChI key

HDOXKDFHZWYVPF-UHFFFAOYSA-N

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This Item
C0992C3117777374
DBCO-Cy3 for Copper-free Click Chemistry

777366

DBCO-Cy3

Anti-Cy3/Cy5 antibody, Mouse monoclonal clone CY-96, purified from hybridoma cell culture

C0992

Anti-Cy3/Cy5 antibody, Mouse monoclonal

Monoclonal Anti-Cy3/Cy5−Biotin antibody produced in mouse ~1 mg/mL, clone CY-96, purified immunoglobulin, buffered aqueous solution

C3117

Monoclonal Anti-Cy3/Cy5−Biotin antibody produced in mouse

DBCO-Cy5 for Copper-free Click Chemistry

777374

DBCO-Cy5

reaction suitability

reaction type: click chemistry

reaction suitability

-

reaction suitability

-

reaction suitability

reaction type: click chemistry

form

solid

form

buffered aqueous solution

form

buffered aqueous solution

form

solid

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

Application

This azadibenzocyclooctyne-cyanine dye derivative is a versatile labeling reagent for detection of azide containing molecules or compounds. Cyclooctynes are useful in strain-promoted copper-free azide-alkyne cycloaddition reactions.This dibenzocyclooctyne will react with azide-functionalized compounds or biomolecules without the need for a Cu(I) catalyst to result in a stable triazole linkage.
Solubility: DMSO; DMF
Abs/Em: 553/563 nm
Extinction Coefficient:: 151,000 cm-1M-1

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
MKCW4774
MKCV8465
MKCN2978
MKCH2293
MKCF1446

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Yoichi Kurumida et al.
Sensors (Basel, Switzerland), 18(8) (2018-08-04)
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Angelina Kasprowicz et al.
Molecules (Basel, Switzerland), 25(19) (2020-10-07)
Monitoring glycosylation changes within cells upon response to stimuli remains challenging because of the complexity of this large family of post-translational modifications (PTMs). We developed an original tool, enabling labeling and visualization of the cell cycle key-regulator β-catenin in its
Ying Zhang et al.
Advanced science (Weinheim, Baden-Wurttemberg, Germany), 8(2), 2003380-2003380 (2021-01-30)
Morphogenesis is a tightly-regulated developmental process by which tissues acquire the morphology that is critical to their function. For example, epithelial cells exhibit different 2D and 3D morphologies, induced by distinct biochemical and biophysical cues from their environment. In this work
Eric R Greene et al.
eLife, 8 (2019-11-30)
The 26S proteasome is essential for proteostasis and the regulation of vital processes through ATP-dependent degradation of ubiquitinated substrates. To accomplish the multi-step degradation process, the proteasome's regulatory particle, consisting of lid and base subcomplexes, undergoes major conformational changes whose
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Articles

Copper-Free Click Chemistry

Copper-free click chemistry is an alternative approach to click chemistry that proceeds at a lower activation barrier and is free of cytotoxic transition metal catalysts.

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