705284
1,1′-Carbonyldiimidazole solution
0.4 M in methylene chloride
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Empirical Formula (Hill Notation):
C7H6N4O
CAS Number:
Molecular Weight:
162.15
Beilstein:
6826
MDL number:
UNSPSC Code:
12352115
PubChem Substance ID:
NACRES:
NA.22
Recommended Products
form
liquid
reaction suitability
reaction type: Carbonylations
concentration
0.4 M in methylene chloride
refractive index
n20/D 1.434
density
1.303 g/mL at 25 °C
SMILES string
O=C(n1ccnc1)n2ccnc2
InChI
1S/C7H6N4O/c12-7(10-3-1-8-5-10)11-4-2-9-6-11/h1-6H
InChI key
PFKFTWBEEFSNDU-UHFFFAOYSA-N
General description
1,1′-Carbonyldiimidazole (N,N′-carbonyldiimidazole) is a versatile peptide-forming reagent.
Application
1,1′-Carbonyldiimidazole (N,N′-carbonyldiimidazole) may be used in the following studies:
- Synthesis of peptides in aqueous solution.
- Synthesis of isoleucine-5 angiotensin II amide-1.
- For the activation of the hydroxyl termini of tween toward nucleophilic addition.
- As coupling reagent for the coupling of prostaglandins and other carboxylic acids to the amino groups of bovine serum albumin.
- Synthesis of peptide thioesters.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Carc. 2 - Eye Dam. 1 - Skin Corr. 1B - STOT SE 3
Target Organs
Central nervous system
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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N,N'-carbonyldiimidazole as coupling reagent for the preparation of bovine serum albumin conjugates.
U Axen
Prostaglandins, 5(1), 45-47 (1974-01-10)
Robert J Chen et al.
Proceedings of the National Academy of Sciences of the United States of America, 100(9), 4984-4989 (2003-04-17)
Novel nanomaterials for bioassay applications represent a rapidly progressing field of nanotechnology and nanobiotechnology. Here, we present an exploration of single-walled carbon nanotubes as a platform for investigating surface-protein and protein-protein binding and developing highly specific electronic biomolecule detectors. Nonspecific
N, N'-Carbonyldiimidazole in Peptide Synthesis. III. 1 A Synthesis of Isoleucine-5 Angiotensin II Amide-I.
Paul R and Anderson GW.
The Journal of Organic Chemistry, 27(6), 2094-2099 (1962)
N,N'-carbonyldiimidazole-induced peptide formation in aqueous solution.
K W Ehler et al.
Biochimica et biophysica acta, 434(1), 233-243 (1976-05-20)
Zain Kassam et al.
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