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538515

Supelco

Fenbufen

96%

Synonym(s):

γ-Oxo-(1,1′-biphenyl)-4-butanoic acid

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About This Item

Linear Formula:
C6H5C6H4CO(CH2)2CO2H
CAS Number:
36330-85-5
Molecular Weight:
254.28
EC Number:
252-979-0
MDL number:
MFCD00056701
UNSPSC Code:
12000000
PubChem Substance ID:
329758009

Assay

96%

mp

184-187 °C (lit.)

SMILES string

OC(=O)CCC(=O)c1ccc(cc1)-c2ccccc2

InChI

1S/C16H14O3/c17-15(10-11-16(18)19)14-8-6-13(7-9-14)12-4-2-1-3-5-12/h1-9H,10-11H2,(H,18,19)

InChI key

ZPAKPRAICRBAOD-UHFFFAOYSA-N

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Product No.
Description
Pricing

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H301

Precautionary Statements

P301 + P310

Hazard Classifications

Acute Tox. 3 Oral

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

新产品

Certificates of Analysis (COA)

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F Kamali et al.
Antimicrobial agents and chemotherapy, 42(5), 1256-1258 (1998-05-21)
The potential effects of concurrent administration of fenbufen and ciprofloxacin on central nervous system activity in healthy young subjects were investigated by electroencephalography (EEG). Visual analog scales (VAS) were used to assess subjective measures of concentration, vigilance, tension, and irritability.
Asif Husain et al.
European journal of medicinal chemistry, 44(9), 3798-3804 (2009-05-22)
The synthesis of a series of 3-[5-(substituted aryl)-1,3,4-oxadiazol-2-yl]-1-(biphenyl-4-yl)propan-1-ones derived from 4-oxo-4-(biphenyl-4-yl)butanoic acid (fenbufen) is described. The structures of these compounds were supported by IR, (1)H NMR, mass spectrometric data and elemental analysis. These compounds were tested for their antiinflammatory, analgesic
Yuan-Hsiao Su et al.
Bioorganic & medicinal chemistry letters, 21(5), 1320-1324 (2011-02-15)
The derivatives with fenbufen and ethacrynic acid core compounds was synthesized through a facial preparation of 1-amino-4-azidobutane. The subsequent coupling with 102 members of carboxylic acids afforded amide products. The in situ screening using colorimetric assay with 3-(4.5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide showed
R N Brogden et al.
Drugs, 21(1), 1-22 (1981-01-01)
Fenbufen is a phenylalkanoic acid derivative with analgesic and anti-inflammatory activity. The anti-inflammatory activity appears to reside in the metabolites. Published data indicate that fenbufen 600 to 1000mg daily is comparable in effectiveness to therapeutic doses (3 to 4g) of
Marta Cruz-Vera et al.
Journal of chromatography. A, 1202(1), 1-7 (2008-07-18)
Dynamic liquid-phase microextraction (dLPME) using an ionic liquid as acceptor phase is proposed for the determination of six non-steroidal anti-inflammatory drugs (NSAIDs) in human urine samples for the first time. The extraction is carried out in a simple and automatic
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