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Safety Information

440191

Sigma-Aldrich

Hexamethyldisilazane

reagent grade, ≥99%

Synonym(s):

Bis(trimethylsilyl)amine, HMDS

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5 G
CN¥1,083.05

CN¥1,083.05

Estimated to ship onJuly 07, 2025Details

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5 G
CN¥1,083.05

About This Item

Linear Formula:
(CH3)3SiNHSi(CH3)3
CAS Number:
999-97-3
Molecular Weight:
161.39
Beilstein:
635752
EC Number:
213-668-5
MDL number:
MFCD00008259
UNSPSC Code:
12352103
PubChem Substance ID:
24867576
NACRES:
NA.23

CN¥1,083.05

Estimated to ship onJuly 07, 2025Details

Request a Bulk Order

grade

reagent grade

Assay

≥99%

form

liquid

refractive index

n20/D 1.407 (lit.)

bp

125 °C (lit.)

SMILES string

C[Si](C)(C)N[Si](C)(C)C

InChI

1S/C6H19NSi2/c1-8(2,3)7-9(4,5)6/h7H,1-6H3

InChI key

FFUAGWLWBBFQJT-UHFFFAOYSA-N

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Show Differences

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This Item
484059327077265519
银 nanopowder, <100 nm particle size, contains PVP as dispersant, 99.5% trace metals basis

576832

银

银 nanopowder, <150 nm particle size, 99% trace metals basis

484059

银

银 flakes, 10 μm, ≥99.9% trace metals basis

327077

银

银 foil, thickness 0.025 mm, 99.9% trace metals basis

265519

银

form

nanopowder

form

nanopowder

form

flakes

form

foil

bp

2212 °C (lit.)

bp

2212 °C (lit.)

bp

2212 °C (lit.)

bp

2212 °C (lit.)

density

10.49 g/cm3 (lit.)

density

10.49 g/cm3 (lit.)

density

10.49 g/cm3 (lit.)

density

10.49 g/cm3 (lit.)

resistivity

1.59 μΩ-cm, 20°C

resistivity

1.59 μΩ-cm, 20°C

resistivity

1.59 μΩ-cm, 20°C

resistivity

1.59 μΩ-cm, 20°C

mp

960 °C (lit.)

mp

960 °C (lit.)

mp

960 °C (lit.)

mp

960 °C (lit.)

General description

Hexamethyldisilane (HMDS) is a stable and effectivereagent for trimethylsilylation of hydrogen-labile substrates such as alcohols,amines, and carboxylic acids. It is commonly used for the protection of sensitivefunctional groups during chemical synthesis. Owing to its low cost, high vapor pressure, and safety, itis widely used as a precursor in chemical vapor deposition(CVD) reactions.

Application

Hexamethyldisilane (HMDS) can be used:
  • As a silylating agent in the trimethylsilylation of alcohols under nearly neutral reaction conditions.
  • To control the molecular weights of polypeptides during ring-opening polymerization of α-amino acid N-carboxyanhydrides.
  • To fabricate silicon carbonitride thin films by plasma-enhanced CVD.
  • For specimen preparation for scanning electron microscopy and the preparation of trimethylsilyl ethers from hydroxy compounds.

Features and Benefits

  • High chemicalstability and low molecular weight
  • Nontoxic andcost-effective reagent
  • Ammonia is theonly byproduct generated during silylation
  • Silylationreaction using HDMS is nearly neutral and does not need any precaution

Pictograms

FlameSkull and crossbones
GHS02,GHS06

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Flam. Liq. 2

Storage Class Code

3 - Flammable liquids

WGK

WGK 2

Flash Point(F)

52.5 °F - closed cup

Flash Point(C)

11.4 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

危险化学品
  • Specification Sheet

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    Certificates of Analysis (COA)

    Lot/Batch Number
    SDBB3148
    STBL0576
    STBK6647
    SHBQ2486
    STBK9636

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    Rapid and highly efficient trimethylsilylation of alcohols and phenols
    with hexamethyldisilazane (HMDS) catalysed by in situ generated I2
    using OxoneR /KI or cerium ammonium nitrate (CAN)/KI systems
    under mild conditions
    Eskandar K, et al.
    Journal of Chemical Sciences (Bangalore), 123(5), 703-708 (2011)
    F Braet et al.
    Journal of microscopy, 186(Pt 1), 84-87 (1997-04-01)
    Critical point drying (CPD) is a common method of drying biological specimens for scanning electron microscopy (SEM). Drying by evaporation of hexamethyldisilazane (HMDS) has been described as a good alternative. This method, however, is infrequently used. Therefore, we reassessed HMDS
    Judith J de Vries et al.
    International journal of molecular sciences, 21(19) (2020-10-01)
    Subjects with diabetes mellitus (DM) have an increased risk of arterial thrombosis, to which changes in clot structure and mechanics may contribute. Another contributing factor might be an increased formation of neutrophil extracellular traps (NETs) in DM. NETs are mainly
    Clyde Savio Pinto et al.
    Scientific reports, 9(1), 12191-12191 (2019-08-23)
    Apical projections are integral functional units of epithelial cells. Microvilli and stereocilia are cylindrical apical projections that are formed of bundled actin. Microridges on the other hand, extend laterally, forming labyrinthine patterns on surfaces of various kinds of squamous epithelial
    Ashang Luwang Laiva et al.
    International journal of pharmaceutics, 483(1-2), 115-123 (2015-02-15)
    Electrospun hybrid nanofibrous scaffolds have gained much importance in the field of tissue engineering and drug delivery applications owing to its multifaceted properties. In this study, the properties of composite polycaprolactone (PCL)/silk fibroin (SF) nanofibrous scaffolds was investigated as a
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