420174
cis-3-Hydroxy-DL-proline
95%
Synonym(s):
(±)-cis-3-Hydroxypyrrolidine-2-carboxylic acid
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About This Item
Empirical Formula (Hill Notation):
C5H9NO3
CAS Number:
Molecular Weight:
131.13
PubChem Substance ID:
UNSPSC Code:
12352200
Beilstein/REAXYS Number:
4130229
MDL number:
SMILES string
O[C@@H]1CCN[C@@H]1C(O)=O
InChI
1S/C5H9NO3/c7-3-1-2-6-4(3)5(8)9/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1
InChI key
BJBUEDPLEOHJGE-DMTCNVIQSA-N
assay
95%
reaction suitability
reaction type: solution phase peptide synthesis
application(s)
peptide synthesis
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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A J Bos et al.
Nihon eiseigaku zasshi. Japanese journal of hygiene, 49(4), 797-806 (1994-10-01)
to observe the influence of aging on urinary secretion of 3-hydroxyproline (3-Hyp) in normal subjects and in cancer patients and study the effects of aging on the accuracy of urinary 3-Hyp as a general-purpose cancer screening test. We reanalyzed, from
Stephen M Krane
Amino acids, 35(4), 703-710 (2008-04-24)
Collagens are among proteins that undergo several post-translational modifications, such as prolyl hydroxylation, that occur during elongation of the nascent chains in the endoplasmic reticulum. The major structural collagens, types I, II and III, have large, uninterrupted triple helices, comprising
David M Hudson et al.
Biochemistry, 51(12), 2417-2424 (2012-03-03)
Proline residues in collagens are extensively hydroxylated post-translationally. A rare form of this modification, (3S,2S)-l-hydroxyproline (3Hyp), remains without a clear function. Disruption of the enzyme complex responsible for prolyl 3-hydroxylation results in severe forms of recessive osteogenesis imperfecta (OI). These
A new rapid method for quantitating radioactive proline, 4-hydroxyproline, and 3-hydroxyproline.
S C Tseng et al.
Analytical biochemistry, 102(2), 291-299 (1980-03-01)
Identification of 3-hydroxyproline residues in several proteins of Fasciola hepatica.
S E Bozas et al.
Experimental parasitology, 82(1), 69-72 (1996-01-01)
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