416274
N-Phenylphthalimide
98%
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About This Item
Empirical Formula (Hill Notation):
C14H9NO2
CAS Number:
Molecular Weight:
223.23
UNSPSC Code:
12352100
PubChem Substance ID:
EC Number:
208-282-9
MDL number:
Assay:
98%
Form:
powder
InChI key
MFUPLJQNEXUUDW-UHFFFAOYSA-N
InChI
1S/C14H9NO2/c16-13-11-8-4-5-9-12(11)14(17)15(13)10-6-2-1-3-7-10/h1-9H
SMILES string
O=C1N(c2ccccc2)C(=O)c3ccccc13
assay
98%
form
powder
mp
204-207 °C (lit.)
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Y Shibata et al.
Chemical & pharmaceutical bulletin, 44(1), 156-162 (1996-01-01)
Phenylphthalimides (2-phenyl-1H-isoindole-1,3-diones) were prepared and their effects on tumor necrosis factor alpha (TNF-alpha) production by human leukemia cell line HL-60 stimulated with 12-O-tetradecanoylphorbol-13-acetate (TPA) were examined. An analysis of the structure-activity relationships of the phenylphthalimides indicated that potent enhancing activity
The oxidative degradation of imide polymers. I: Ozonolysis of a model compound, N-phenylphthalimide.
Barman S, et al.
Polym. Eng. Sci., 34(4), 279-284 (1994)
Masashi Tetsuhashi et al.
Bioorganic & medicinal chemistry, 18(14), 5323-5338 (2010-06-22)
A novel series of tryptase inhibitors with a N-phenylphthalimide skeleton structurally derived from thalidomide (1) has been developed. Structure-activity relationship studies led to a potent and selective tryptase inhibitor, 2-(4-cyanophenyl)isoindole-1,3-dione-5-yl 3-(2-aminopyridin-5-yl)propanoate (7), with the IC50 value of 78 nM.
H Takahashi et al.
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 120(10), 909-921 (2000-11-18)
The studies on both structure-activity relationship study and identification of the target enzyme of novel nonpeptide aminopeptidase inhibitors with cyclic imide skeleton are reviewed. Some N-phenylphthalimide or N-phenylhomophthalimide derivative showed potent protease inhibitory activity in an assay system using human
Hiroko Sano et al.
Chemical & pharmaceutical bulletin, 52(8), 1021-1022 (2004-08-12)
Several N-substituted phenylphthalimide and phenylhomophthalimide derivatives with cyclooxygenase (COX)-inhibitory activity were prepared during structural development studies based on thalidomide as a lead compound. Substituent effects on the subtype selectivity were investigated.
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