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240230

Sigma-Aldrich

Phthalimide

≥99%

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Synonym(s):
1,3-Dihydro-1,3-dioxoisoindole
Empirical Formula (Hill Notation):
C8H5NO2
CAS Number:
Molecular Weight:
147.13
Beilstein:
118522
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22

Quality Level

Assay

≥99%

mp

232-235 °C (lit.)

solubility

water: slightly soluble(lit.)

SMILES string

O=C1NC(=O)c2ccccc12

InChI

1S/C8H5NO2/c10-7-5-3-1-2-4-6(5)8(11)9-7/h1-4H,(H,9,10,11)

InChI key

XKJCHHZQLQNZHY-UHFFFAOYSA-N

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Application

Phthalimide was used in the synthesis of 6-amino agarose (AA) by Mitsunobu-inspired microwave mediated method.

WGK

WGK 1

Flash Point(F)

302.0 °F

Flash Point(C)

150 °C

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

危险化学品

Certificates of Analysis (COA)

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Alessio Pierini et al.
Journal of veterinary science, 21(5), e60-e60 (2020-10-06)
Tumor-associated neoangiogenesis is a crucial target for antitumor therapies. Thalidomide (TAL) is a promising anti-neoangiogenetic drug that has recently been used in the treatment of several malignancies in dogs. The aim of the study was to assess the pharmacokinetics of
Ive Hermans et al.
Physical chemistry chemical physics : PCCP, 10(8), 1125-1132 (2008-02-14)
Abstraction of hydrogen atoms by pthalimide-N-oxyl radicals is an important step in the N-hydroxyphthalimide catalyzed autoxidation of hydrocarbons. In this contribution, the temperature dependency of this reaction is evaluated by a detailed transition state theory based kinetic analysis for the
Ioannis Fitilis et al.
The journal of physical chemistry. A, 112(21), 4742-4748 (2008-05-08)
Two photon absorption (TPA) and photophysical properties of three new symmetrical chromophores with electron accepting phthalimide edge substituents have been studied. The three chromophores contain fluorene, alcoxy-substituted divinyl benzene, and carbazole moieties as central cores, respectively. The femtosecond time-resolved fluorescence
Kazuaki Ishihara et al.
Organic letters, 10(13), 2893-2896 (2008-06-07)
Catalytic and highly enantioselective Diels-Alder reaction of cyclic and acyclic dienes with alpha-phthalimidoacroleins provides cyclic alpha-quaternary alpha-amino acid precursors. The conformationally flexible chiral ammonium salt of H-L-Phe-L-Leu-N(CH(2)CH(2)) 2-reduced triamine with pentafluorobenzensulfonic acid is very effective as an asymmetric catalyst for
Heloise Brice et al.
Chemical communications (Cambridge, England), 48(40), 4836-4838 (2012-04-14)
A range of chiral, optically-enriched bicyclic oxabispidines were prepared from (S)-(-)-2,3-epoxypropylphthalimide using an efficient sequence featuring a stereocontrolled intramolecular Mannich reaction as the key transformation.

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