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409537

Sigma-Aldrich

Poly(ethylene glycol) methacrylate

average Mn 360, methacrylate, 500-800 ppm MEHQ as inhibitor

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Synonym(s):
Ethoxylated 2-hydroxyethyl methacrylate, PEGMA, Poly(ethylene oxide) monomethacrylate, Polyethylene glycol
Linear Formula:
H2C=C(CH3)CO(OCH2CH2)nOH
CAS Number:
25736-86-1
MDL number:
MFCD00081879
UNSPSC Code:
12162002
NACRES:
NA.23

form

liquid

Quality Level

200

mol wt

average Mn 360

contains

500-800 ppm MEHQ as inhibitor

reaction suitability

reagent type: cross-linking reagent
reaction type: Polymerization Reactions

refractive index

n20/D 1.464

density

1.105 g/mL at 25 °C

Ω-end

hydroxyl

α-end

methacrylate

polymer architecture

shape: linear
functionality: heterobifunctional

InChI

1S/C6H10O3/c1-5(2)6(8)9-4-3-7/h7H,1,3-4H2,2H3

InChI key

WOBHKFSMXKNTIM-UHFFFAOYSA-N

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General description

Polyethylene glycol (PEG) is a suitable material for biological applications since it does not trigger an immune response. It can by synthesized by anionic ring opening polymerization of ethylene oxide with a range of end groups (such as methacrylate: PEGMA) attached. PEG is a hydrophilic polymer that can form hydrogels when cross linked into networks. Acrylate and methacrylate chain ends undergo chain polymerization to from PEGMA hydrogels.

Application

PEGMA can beused as a monomer to synthesize:
  • Degradable microspheres using asuspension polymerization process. The amphiphilic nature of PEGMA allows performingthe polymerization by direct oil in the water suspension process.
  • Polymeric chelating beads for the effectiveremoval of heavy metals from aqueous solutions.
It can also be used to synthesize micro or nanoparticles-basedchitosan /PEGMA composite by Michael addition reaction. The PEGMA graftingimproves the solubility of chitosan in aqueous media. These particles can beused as carriers in the ophthalmic drug delivery system.

Physical form

Monomethacrylate functionalized

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315

Hazard Classifications

Skin Irrit. 2

WGK

WGK 3

Flash Point(F)

closed cup

Flash Point(C)

closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Mir Mukkaram Ali;
Macromolecules, 37, 5219-5227 (2004)
Biofouling-resistance expanded poly (tetrafluoroethylene) membrane with a hydrogel-like layer of surface-immobilized poly (ethylene glycol) methacrylate for human plasma protein repulsions.
Chang Y, et al.
Journal of Membrane Science, 323(1), 77-84 (2008)

Articles

Degradable Poly(ethylene glycol) Hydrogels for 2D and 3D Cell Culture

Progress in biotechnology fields such as tissue engineering and drug delivery is accompanied by an increasing demand for diverse functional biomaterials. One class of biomaterials that has been the subject of intense research interest is hydrogels, because they closely mimic the natural environment of cells, both chemically and physically and therefore can be used as support to grow cells. This article specifically discusses poly(ethylene glycol) (PEG) hydrogels, which are good for biological applications because they do not generally elicit an immune response. PEGs offer a readily available, easy to modify polymer for widespread use in hydrogel fabrication, including 2D and 3D scaffold for tissue culture. The degradable linkages also enable a variety of applications for release of therapeutic agents.

Versatile Cell Culture Scaffolds: Bio-orthogonal Click

Designing biomaterial scaffolds mimicking complex living tissue structures is crucial for tissue engineering and regenerative medicine advancements.

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