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Sigma-Aldrich

Hexaethylene glycol

97%, average MN 300

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Synonym(s):
Polyethylene glycol, 3,6,9,12,15-Pentaoxaheptadecane-1,17-diol
Linear Formula:
H(OCH2CH2)6OH
CAS Number:
2615-15-8
Molecular Weight:
282.33
Beilstein:
1638281
EC Number:
220-045-1
MDL number:
MFCD00002877
UNSPSC Code:
12162002
PubChem Substance ID:
24855697
NACRES:
NA.23

Quality Level

200

Assay

97%

form

liquid

mol wt

average Mn 300

refractive index

n20/D 1.465 (lit.)

bp

217 °C/4 mmHg (lit.)

mp

5-7 °C (lit.)

density

1.127 g/mL at 25 °C (lit.)

Ω-end

hydroxyl

α-end

hydroxyl

SMILES string

OCCOCCOCCOCCOCCOCCO

InChI

1S/C12H26O7/c13-1-3-15-5-7-17-9-11-19-12-10-18-8-6-16-4-2-14/h13-14H,1-12H2

InChI key

IIRDTKBZINWQAW-UHFFFAOYSA-N

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Application

Substrate employed in the synthesis of binaphthol-based macrocyclic ethers using intramolecular oxidative coupling with CuCl(OH)-TMEDA.

WGK

WGK 2

Flash Point(F)

No data available

Flash Point(C)

No data available

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Paul A Bertin et al.
Journal of the American Chemical Society, 128(13), 4168-4169 (2006-03-30)
We present a rational approach for assembling diverse bioactive agents, such as DNA, proteins, and drug molecules, into core-shell multifunctional polymeric nanoparticles (PNPs) that can be internalized in human breast cancer cells. Using ring-opening metathesis polymerization (ROMP), block copolymers containing
Dorota Bartczak et al.
Nanoscale, 4(15), 4470-4472 (2012-06-30)
We present the exocytosis profile of two types of peptide-coated nanoparticles, which have similar charge and size but different functionality. While one kind of particles appears to progressively exocytose, the other one has a more complex profile, suggesting that some
Xin Li et al.
Analytical chemistry, 84(6), 2609-2613 (2012-03-03)
Lipophilicity of chemicals and drug candidates is normally described in terms of octanol/water partitioning and log P. We investigated an alternate approach to lipophilicity determination using a mimic of an alkyl alcohol with compound partitioning quantified using acoustic sensing. A
Pavel Vorobjev et al.
Nucleosides, nucleotides & nucleic acids, 23(6-7), 1047-1051 (2004-11-25)
New conjugates of bleomycin A5 with oligonucleotides are synthesized. The bleomycin residue was attached to the 3'- or 5'- terminus of hexadecathymidilate via a hexaethylene glycol phosphate linker. Newly designed conjugates were shown to cleave site-specifically both strands of a
Ewelina Burakowska et al.
Small (Weinheim an der Bergstrasse, Germany), 5(19), 2199-2204 (2009-07-03)
A convenient methodology for the synthesis of photolabile crosslinked hyperbranched polyglycerol nanocapsules is presented. These nanocarriers selectively and efficiently bind ionic guest molecules. The stability of the host-guest complexes formed depends on the counterion of the guest molecules. Moreover, the
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Articles

Degradable Poly(ethylene glycol) Hydrogels for 2D and 3D Cell Culture

Progress in biotechnology fields such as tissue engineering and drug delivery is accompanied by an increasing demand for diverse functional biomaterials. One class of biomaterials that has been the subject of intense research interest is hydrogels, because they closely mimic the natural environment of cells, both chemically and physically and therefore can be used as support to grow cells. This article specifically discusses poly(ethylene glycol) (PEG) hydrogels, which are good for biological applications because they do not generally elicit an immune response. PEGs offer a readily available, easy to modify polymer for widespread use in hydrogel fabrication, including 2D and 3D scaffold for tissue culture. The degradable linkages also enable a variety of applications for release of therapeutic agents.

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