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240931

Sigma-Aldrich

Saccharin

≥99%

Synonym(s):

2,3-Dihydroxy-1,2-benzisothiazol-3-one-1,1-dioxide, 2-Sulfobenzoic acid imide, o-Benzoic sulfimide

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1 G
CN¥479.76
50 G
CN¥1,195.10

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1 G
CN¥479.76
50 G
CN¥1,195.10

About This Item

Empirical Formula (Hill Notation):
C7H5NO3S
CAS Number:
81-07-2
Molecular Weight:
183.18
Beilstein:
6888
EC Number:
201-321-0
MDL number:
MFCD00005866
UNSPSC Code:
12352100
PubChem Substance ID:
24854444
NACRES:
NA.22

CN¥479.76

Available to ship onApril 27, 2025Details

Request a Bulk Order

Quality Level

200

Assay

≥99%

form

powder

mp

226-229 °C (lit.)

solubility

acetone: 1g in 12mL(lit.)
alcohol: 1g in 31mL(lit.)
boiling water: 1g in 25mL(lit.)
water: 1g in 25mL(lit.)

SMILES string

O=C1NS(=O)(=O)c2ccccc12

InChI

1S/C7H5NO3S/c9-7-5-3-1-2-4-6(5)12(10,11)8-7/h1-4H,(H,8,9)

InChI key

CVHZOJJKTDOEJC-UHFFFAOYSA-N

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Show Differences

1 of 4

This Item
PHR134110918541131
Saccharin ≥99%

240931

Saccharin

Saccharin Pharmaceutical Secondary Standard; Certified Reference Material

PHR1341

Saccharin

Saccharin ≥98%

109185

Saccharin

Mettler-Toledo Calibration substance ME 51143091, Saccharin traceable to primary standards (LGC)

41131

Mettler-Toledo Calibration substance ME 51143091, Saccharin

assay

≥99%

assay

-

assay

≥98%

assay

-

Quality Level

200

Quality Level

300

Quality Level

100

Quality Level

100

solubility

acetone: 1g in 12mL(lit.), boiling water: 1g in 25mL(lit.), alcohol: 1g in 31mL(lit.)

solubility

-

solubility

H2O: soluble 1g in 290ml, acetone: soluble 1g in 12ml, alcohol: soluble 1g in 31ml, boiling water: soluble 1g in 25ml, glycerol: soluble 1g in 50ml, alcohol: very slightly soluble, chloroform: slightly soluble, diethyl ether: slightly soluble

solubility

-

mp

226-229 °C (lit.)

mp

226-229 °C (lit.)

mp

226-229 °C (lit.)

mp

226-229 °C (lit.)

form

powder

form

-

form

-

form

-

General description

The biodegradation of saccharin (2-sulfobenzoic acid imide), an artificial sweetening agent, was studied[1]. It was also studied for its carcinogenic potential.

Application


  • Gabapentin-saccharin co-crystals with enhanced physicochemical properties and in vivo absorption formulated as oro-dispersible tablets.: This study presents the formulation of gabapentin-saccharin co-crystals, demonstrating improved solubility and absorption, beneficial for pharmaceutical applications (Soliman et al., 2020, doi: 10.1080/10837450.2019.1687521).

  • Improving the solubility, dissolution, and bioavailability of Ibrutinib by preparing it in a coamorphous state with saccharin.: The research focuses on enhancing the bioavailability of Ibrutinib through coamorphous preparation with saccharin, which is significant for cancer treatment (Shi et al., 2019, doi: 10.1016/j.xphs.2019.04.031).

Biochem/physiol Actions

A sweet tastant for mammals. A glycerol taste receptor binding site specific for glucose has been proposed in drosophila.

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves
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    Certificates of Analysis (COA)

    Lot/Batch Number
    MKCX0199
    MKCV4162
    MKCS3078
    MKCS1794
    MKCN2685

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    N H Tran et al.
    Bioresource technology, 161, 40-46 (2014-04-01)
    The biodegradation of the six artificial sweetening agents including acesulfame (ACE), aspartame (ASP), cyclamate (CYC), neohesperidindihydrochalcone (NHDC), saccharin (SAC), and sucralose (SUC) by nitrifying activated sludge was first examined. Experimental results showed that ASP and NHDC were the most easily
    Hellmuth Lilienthal et al.
    Toxicology, 311(1-2), 52-60 (2013-02-14)
    Many chemicals are known to exhibit endocrine activity and affect reproductive functions in vertebrates and invertebrates. Endocrine effects include influences on sexual differentiation of the brain during development and reproductive and non-reproductive behavior in adult offspring. We previously demonstrated that
    Hugh P Morgan et al.
    The Biochemical journal, 448(1), 67-72 (2012-08-22)
    PYK (pyruvate kinase) plays a central role in the metabolism of many organisms and cell types, but the elucidation of the details of its function in a systems biology context has been hampered by the lack of specific high-affinity small-molecule
    Rino Ragno et al.
    Journal of medicinal chemistry, 50(6), 1241-1253 (2007-02-28)
    The screening of the inhibition capabilities of dye-like small molecules from a focused library against both human PRMT1 and Aspergillus nidulans RmtA is reported as well as molecular modeling studies (homology modeling, molecular docking, and 3-D QSAR) of the catalytic
    Katharine J Tuerke et al.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(40), 13709-13717 (2012-10-05)
    A taste associated with emetic drugs produces conditioned disgust reactions in rats (predominantly gaping), unlike nonemetic drugs that can still produce conditioned taste avoidance but not conditioned disgust. That difference suggests nausea is a prerequisite for learning disgust reactions to
    View All Related Papers

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