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S6047

Sigma-Aldrich

Saccharin sodium salt hydrate

BioXtra, ≥99%

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Synonym(s):
2,3-Dihydro-3-oxobenzisosulfonazole sodium salt, 2-Sulfobenzoic acid imide sodium salt, o-Sulfobenzimide sodium salt, Saccharin soluble
Empirical Formula (Hill Notation):
C7H4NNaO3S · xH2O
CAS Number:
82385-42-0
Molecular Weight:
205.17 (anhydrous basis)
Beilstein:
3599229
EC Number:
204-886-1
MDL number:
MFCD00149605
UNSPSC Code:
12352200
PubChem Substance ID:
24899685
NACRES:
NA.25

product line

BioXtra

Quality Level

200

Assay

≥99%

form

powder

sweetness

300 × sucrose

impurities

≤0.0005% Phosphorus (P)
≤0.1% Insoluble matter

solubility

H2O: 1 M at 20 °C, clear, colorless

anion traces

chloride (Cl-): ≤0.05%
sulfate (SO42-): ≤0.05%

cation traces

Al: ≤0.0005%
Ca: ≤0.005%
Cu: ≤0.0005%
Fe: ≤0.0005%
K: ≤0.005%
Mg: ≤0.001%
NH4+: ≤0.05%
Pb: ≤0.001%
Zn: ≤0.0005%

SMILES string

[Na+].[H]O[H].[O-]C1=NS(=O)(=O)c2ccccc12

InChI

1S/C7H5NO3S.Na.H2O/c9-7-5-3-1-2-4-6(5)12(10,11)8-7;;/h1-4H,(H,8,9);;1H2/q;+1;/p-1

InChI key

ILJOYZVVZZFIKA-UHFFFAOYSA-M

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General description

Saccharin is an artificial sweetener, which is used in canned fruit juices, vegetables, cookies and jellies. It is associated with bladder cancer.

Application

Saccharin sodium salt hydrate has been used to eliminate the potentially confounding effect of caloric content. It has also been used to study its effects on the cyclamate-responsive taste 2 receptor member 1 (TAS2R1) receptor.

Biochem/physiol Actions

′First generation′ synthetic sugar alternative that has been studied for its carcinogenic potential.

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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FGF21 regulates sweet and alcohol preference
Talukdar S, et al.
Cell Metabolism, 23(2), 344-349 (2016)
Blends of non-caloric sweeteners saccharin and cyclamate show reduced off-taste due to TAS2R bitter receptor inhibition
Behrens M, et al.
Cell Chemical Biology, 24(10), 1199-1204 (2017)
Robert A Boakes et al.
Physiology & behavior, 218, 112822-112822 (2020-02-01)
Rats first given 24-h access to 10% sucrose for 4 or 12 days (Stage 1) were then switched to a saccharin solution for a 12-day Stage 2. The initial result of this switch was that these Sucrose groups drank less
Simone Rehn et al.
Physiology & behavior, 207, 15-27 (2019-05-06)
When animals are given access to a palatable food or drink on some days but not on others, the amount they consume can far exceed the daily amounts consumed by controls given daily access. A previous study demonstrated such bingeing
Jennifer K Roebber et al.
Pharmacology, biochemistry, and behavior, 133, 18-24 (2015-03-31)
In rodents, saccharin consumption is suppressed when the sweet taste stimulus is paired with moderate doses of cocaine. Several hypotheses have been used to explain the seemingly contradictory effect of decreased consumption of a normally preferred substance following a highly
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