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Safety Information

184047

Sigma-Aldrich

(S)-(+)-Leucinol

96%

Synonym(s):

(S)-2-Amino-4-methyl-1-pentanol, 2-Amino-4-methyl-1-pentanol, L-Leucinol

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About This Item

Linear Formula:
(CH3)2CHCH2CH(NH2)CH2OH
CAS Number:
7533-40-6
Molecular Weight:
117.19
Beilstein:
1719240
EC Number:
231-400-5
MDL number:
MFCD00063676
UNSPSC Code:
12352200
PubChem Substance ID:
24851088

Assay

96%

optical activity

[α]20/D +4°, c = 9 in ethanol

optical purity

ee: 99% (GLC)

reaction suitability

reaction type: solution phase peptide synthesis

refractive index

n20/D 1.4511 (lit.)

bp

198-200 °C/768 mmHg (lit.)

density

0.917 g/mL at 25 °C (lit.)

application(s)

peptide synthesis

SMILES string

CC(C)C[C@H](N)CO

InChI

1S/C6H15NO/c1-5(2)3-6(7)4-8/h5-6,8H,3-4,7H2,1-2H3/t6-/m0/s1

InChI key

VPSSPAXIFBTOHY-LURJTMIESA-N

Application

Starting material for the synthesis of aminopeptidase N and phospholipase A2 inhibitors.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

195.8 °F - closed cup

Flash Point(C)

91 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
17923HU
15608HO
10501CG
06509KI
04509HI

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A convenient method using a fluorogenic agent, 4-chloro-7-nitro-1,2,3-benzoxadiazole (NBD-Cl), was developed for enantiomer separation of chiral aliphatic amines including amino alcohols by normal high-performance liquid chromatography. The enantiomer separation of chiral aliphatic amines as NBD derivatives was performed on six
C Bennion et al.
Journal of medicinal chemistry, 35(16), 2939-2951 (1992-08-07)
A series of substrate analogue inhibitors of pancreatic phospholipase A2 has been designed and synthesized. The compounds were tested in a novel dual-screening system based on parallel assays with monomeric and micellar substrates. Intermolecular nuclear Overhauser effects between vinylic protons
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Journal of the American Chemical Society, 132(51), 18051-18053 (2010-12-04)
Experiments have shown that enantiospecificity can be important in wetting. Measurements of droplet contact angles can be used to estimate the energy of enantiomeric discrimination.
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Journal of cellular biochemistry, 79(3), 427-441 (2000-09-06)
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