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117455

Sigma-Aldrich

p-Toluenesulfonyl fluoride

98%

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Linear Formula:
CH3C6H4SO2F
CAS Number:
Molecular Weight:
174.19
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22

Quality Level

Assay

98%

form

solid

reaction suitability

reaction type: click chemistry

bp

112 °C/16 mmHg (lit.)

mp

41-42 °C (lit.)

SMILES string

Cc1ccc(cc1)S(F)(=O)=O

InChI

1S/C7H7FO2S/c1-6-2-4-7(5-3-6)11(8,9)10/h2-5H,1H3

InChI key

IZZYABADQVQHLC-UHFFFAOYSA-N

General description

p-Toluenesulfonyl fluoride is a peroxygen bleach activator and is also useful in the treatment of Alzheimer′s disease.

Application

p-Toluenesulfonyl fluoride was used to study the DNS polymerase from spinach leaf extracts. It was used in isolation and separation of Pseudomonas aeruginosa membranes by density sucrose gradient centrifugation.
Protease inhibitor.

Pictograms

CorrosionExclamation mark

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 4 Oral - Skin Corr. 1B

WGK

WGK 3

Flash Point(F)

closed cup

Flash Point(C)

closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Andrea Schmidt et al.
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A series of crystal structures of trypsin, containing either an autoproteolytic cleaved peptide fragment or a covalently bound inhibitor, were determined at atomic and ultra-high resolution and subjected to ab initio quantum chemical calculations and multipole refinement. Quantum chemical calculations
Novelties of solid-liquid phase transfer catalysed synthesis of p-toluenesulfonyl fluoride from p-toluenesulfonyl chloride.
Yadav GD and Paranjape PM.
Journal of Fluorine Chemistry, 126(3), 289-295 (2005)
Pyo-Jam Park et al.
Journal of biochemistry and molecular biology, 35(6), 576-582 (2002-12-10)
Collagenase from the internal organs of a mackerel was purified using acetone precipitation, ion-exchange chromatography on a DEAE-Sephadex A-50, gel filtration chromatography on a Sephadex G-100, ion-exchange chromatography on DEAE-Sephacel, and gel filtration chromatography on a Sephadex G-75 column. The
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International journal of biological macromolecules, 50(5), 1238-1244 (2012-04-26)
A lipolytic activity was located in the chicken uropygial glands, from which a carboxylesterase (CUE) was purified. Pure CUE has an apparent molecular mass of 50 kDa. The purified esterase displayed its maximal activity (200 U/mg) on short-chain triacylglycerols (tributyrin)
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Protein science : a publication of the Protein Society, 14(2), 558-565 (2005-01-06)
Growth-limiting stresses in bacteria induce the general stress response to protect the cells against future stresses. Energy stress caused by starvation conditions in Bacillus subtilis is transmitted to the sigma(B) transcription factor by stress-response regulators. RsbP, a positive regulator, is

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