107255
3-Hydroxy-2-nitropyridine
97%
Synonym(s):
2-Nitro-3-pyridinol
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About This Item
Empirical Formula (Hill Notation):
C5H4N2O3
CAS Number:
Molecular Weight:
140.10
UNSPSC Code:
12352100
PubChem Substance ID:
EC Number:
239-191-2
MDL number:
Product Name
3-Hydroxy-2-nitropyridine, 97%
assay
97%
form
solid
InChI key
QBPDSKPWYWIHGA-UHFFFAOYSA-N
InChI
1S/C5H4N2O3/c8-4-2-1-3-6-5(4)7(9)10/h1-3,8H
SMILES string
Oc1cccnc1[N+]([O-])=O
mp
69-71 °C (lit.)
functional group
nitro
Application
3-Hydroxy-2-nitropyridine may be used in the synthesis of novel sulfonates that are potent inhibitors of cell proliferation and tubulin polymerization.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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S L Gwaltney et al.
Bioorganic & medicinal chemistry letters, 11(13), 1671-1673 (2001-06-27)
The synthesis and biological evaluation of novel sulfonate analogues of E-7010 are reported. Several of the compounds are potent inhibitors of cell proliferation and tubulin polymerization. Importantly, these compounds are also active against P-glycoprotein positive (+) cancer cells, which are
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