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Merck
CN

Novel sulfonate derivatives: potent antimitotic agents.

Bioorganic & medicinal chemistry letters (2001-06-27)
S L Gwaltney, H M Imade, Q Li, L Gehrke, R B Credo, R B Warner, J Y Lee, P Kovar, D Frost, S C Ng, H L Sham
PMID11425534
ABSTRACT

The synthesis and biological evaluation of novel sulfonate analogues of E-7010 are reported. Several of the compounds are potent inhibitors of cell proliferation and tubulin polymerization. Importantly, these compounds are also active against P-glycoprotein positive (+) cancer cells, which are resistant to many other antitumor agents.