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mAbs Characterization & Quality Control

The key for ensuring drug safety and efficacy

HomeIntegrated OfferingsMonoclonal Antibodies (mAbs)Characterization and Quality ControlPost-Translational Modification Analysis

 

Characterization and quality control of monoclonal antibodies (mAbs) is essential to ensure their efficacy and safety. Analytical techniques, like HPLC and mass spectrometry, are vital to assess various properties, such as aggregation, charge variants, and post-translational modifications (PTMs). Our extensive selection of products supports the detailed analysis and evaluation of mAbs to maintain quality and effectiveness. 

Characterization and Quality Control
Intact Mass Analysis
Peptide Mapping
Post-Translational Modification Analysis
Aggregate Analysis
Titer Determination
Microbiological Testing

Post-Translational Modification Analysis of Monoclonal Antibodies

Post-translational modification analysis of monoclonal antibodies (mAbs) assesses product consistency, efficacy, and safety. To identify and quantify PTMs in mAbs, mass spectrometry and chromatography are commonly used. High-purity solvents are used to prevent contamination and ensure consistency. HPLC columns separate and quantify different components of the mAb sample. Analytical reagents are used for characterization and detection of mAbs. Glycobiology profiling tools are used to analyze the carbohydrate structures of mAbs.

We offer all the tools you need to monitor and ensure the consistency, quality, and safety of mAbs across various stages of the mAb production workflow.

Related Categories

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HPLC Columns

Explore RPC, SEC, IEC, HILIC, and IMAC columns.

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High-Purity Solvents

Use our highest grade of solvents in mAb production to minimize the risk of impurities.

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Analytical Reagents

Count on our high-quality reagents for analytical characterization in various stages of mAb production.

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Glycobiology Profiling Tools

Find glycosidases and glycobiology reagents and kits to support glycobiology profiling of mAbs.

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Related Webinars

Efficient Analyses of Proteins

Discover how to maximize efficiency and resolution when using reversed phase chromatography (RPC) and size exclusion chromatography (SEC).

Tips & Tricks to Improve MS Sensitivity

Learn how to enable and maintain high quality and high sensitivity in LC-MS analyses by preventing impurities and contaminations.

Improving Bioanalysis Workflows

Explore a simple and high throughput method for the quantitation of monoclonal antibodies and proteins in human and animal serum.

Related Applications
Viable Air Monitoring
Microbial air monitoring is a critical step in maintaining aseptic environments, cleanrooms and production areas to ensure the quality of raw materials and finished products.
Sterility Testing
Sterility testing is an essential process necessary for sterilization validation. Membrane filtration is a preferred method for sterility testing of pharmaceuticals, food and beverages, tissue materials and other products that claim to be sterile.
Microbial Culture Media Preparation
Culture media provides essential nutrients for the cultivation of microbes. They also contain inhibitors for selective growth of specific microorganisms.
Bioburden Testing
Bioburden testing measures the levels of microbial contamination in water, raw materials, and finished products.
Media Fills
Media fill is a critical microbiological test carried out to assess the performance of an aseptic manufacturing process by replacing the pharmaceutical or beverage product with a sterile culture medium.
Surface & Personnel Testing
Surface monitoring and personnel monitoring measure the levels of microbial contamination in production areas to control the measures of disinfection routines.
Mass Spectrometry
Mass spectrometry (MS) is an analytical tool used to identify compounds, determine chemical structure, and assess isotopic abundance. In MS, samples are ionized, and the resulting ions are identified based on their mass-to-charge (m/z) ratios.
Large Molecule HPLC
High performance liquid chromatography (HPLC) can be used to separate and identify different large biomolecules such as protein and peptides in a sample. It is based on the pumping of a sample with a solvent (mobile phase) through a column packed with sorbent material (stationary phase) at a high pressure.

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Immunoglobulin G antibody in blue and yellow
Antibody Drug Discovery
Female lab worker wearing safety goggles and nitrile gloves prepares solution of reagents in beakers with blue and pink liquid.
Characterization & Quality Control
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