SML1992
FM-479
≥98% (HPLC)
别名:
(E)-2-Cyano-3-(5-(1-cyclohexyl-6-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)furan-2-yl)-N,N-dimethylacrylamide, 2-Cyano-3-(5-(1-cyclohexyl-6-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)furan-2-yl)-N,N-dimethylacrylamide, FM-381 Inactive Control
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所有图片(1)
About This Item
生化/生理作用
FM-479 is an FM-381 structural analog that exhibits no inhibitory potency against JAK3 or other kinases when used at the FM-381 effective dosing range of 100-300 nM. For characterization details of the active probe, FM-381, please visit the FM-381 probe summary on the Structural Genomics Consortium (SGC) website.
FM-381, the active probe, is available from Sigma. To learn more about and purchase FM-381, click here.
To learn about other SGC chemical probes, visit sigma.com/sgc
FM-381, the active probe, is available from Sigma. To learn more about and purchase FM-381, click here.
To learn about other SGC chemical probes, visit sigma.com/sgc
特点和优势
FM-479 is a negative control for FM-381, a chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC chemical probes, visit sigma.com/SGC
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Michael Forster et al.
Cell chemical biology, 23(11), 1335-1340 (2016-11-15)
Janus kinases (JAKs) are a family of cytoplasmatic tyrosine kinases that are attractive targets for the development of anti-inflammatory drugs given their roles in cytokine signaling. One question regarding JAKs and their inhibitors that remains under intensive debate is whether
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