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Safety Information

SML1992

Sigma-Aldrich

FM-479

≥98% (HPLC)

Synonym(s):

(E)-2-Cyano-3-(5-(1-cyclohexyl-6-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)furan-2-yl)-N,N-dimethylacrylamide, 2-Cyano-3-(5-(1-cyclohexyl-6-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)furan-2-yl)-N,N-dimethylacrylamide, FM-381 Inactive Control

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250 G
CN¥1,000.26
1 KG
CN¥4,616.55

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250 G
CN¥1,000.26
1 KG
CN¥4,616.55

About This Item

Empirical Formula (Hill Notation):
C25H26N6O2
CAS Number:
Molecular Weight:
442.51
UNSPSC Code:
12352200
NACRES:
NA.77

CN¥1,000.26

List priceCN¥1,445.76Save 31%

Available to ship onApril 09, 2025Details


Request a Bulk Order

Assay

≥98% (HPLC)

form

powder

color

yellow to orange

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

CN(C(/C(C#N)=C/C(O1)=CC=C1C2=NC3=CN=C(N(C)C=C4)C4=C3N2C5CCCCC5)=O)C

InChI

1S/C25H26N6O2/c1-29(2)25(32)16(14-26)13-18-9-10-21(33-18)24-28-20-15-27-23-19(11-12-30(23)3)22(20)31(24)17-7-5-4-6-8-17/h9-13,15,17H,4-8H2,1-3H3/b16-13+

InChI key

RPIGHLXKDWUGDT-DTQAZKPQSA-N

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Show Differences

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Quality Level

200

Quality Level

100

Quality Level

200

Quality Level

100

assay

≥99.9% (GC)

assay

≥99.8% (GC)

assay

≥99.8% (GC)

assay

-

technique(s)

HPLC: suitable

technique(s)

HPLC: suitable

technique(s)

-

technique(s)

-

form

liquid

form

liquid

form

liquid

form

-

vapor pressure

128 hPa ( 20 °C), 97.68 mmHg ( 20 °C), 410 mmHg ( 50 °C)

vapor pressure

128 hPa ( 20 °C), 410 mmHg ( 50 °C), 97.68 mmHg ( 20 °C)

vapor pressure

128 hPa ( 20 °C), 410 mmHg ( 50 °C), 97.68 mmHg ( 20 °C)

vapor pressure

410 mmHg ( 50 °C), 97.68 mmHg ( 20 °C)

Biochem/physiol Actions

FM-479 is an FM-381 structural analog that exhibits no inhibitory potency against JAK3 or other kinases when used at the FM-381 effective dosing range of 100-300 nM. For characterization details of the active probe, FM-381, please visit the FM-381 probe summary on the Structural Genomics Consortium (SGC) website.

FM-381, the active probe, is available from Sigma. To learn more about and purchase FM-381, click here.

To learn about other SGC chemical probes, visit sigma.com/sgc
Inactive FM-381 structural analog.

Features and Benefits

FM-479 is a negative control for FM-381, a chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC chemical probes, visit sigma.com/SGC

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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    Michael Forster et al.
    Cell chemical biology, 23(11), 1335-1340 (2016-11-15)
    Janus kinases (JAKs) are a family of cytoplasmatic tyrosine kinases that are attractive targets for the development of anti-inflammatory drugs given their roles in cytokine signaling. One question regarding JAKs and their inhibitors that remains under intensive debate is whether

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