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生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
形式
buffered aqueous solution
种属反应性
human, mouse, rat
技术
immunocytochemistry: suitable
indirect ELISA: suitable
western blot: suitable
NCBI登记号
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... TCF12(6938)
一般描述
Transcription factor 12 (TCF12) is a class I member of helix-loop-helix (HLH) protein family, encodes for class II basic helix-loop-helix protein (bHLHb) transcription factor. In human chromosome, the gene TCF12 is localized on 15q21.3.
免疫原
TCF12 antibody was raised against a 19 amino acid peptide near the amino terminus of human TCF12.
应用
Anti-TCF12 antibody produced in rabbit has been used in immunoblotting.
生化/生理作用
Transcription factor 12 (TCF12) represses E-cadherin expression and thereby controls metastasis of colorectal cancer cells. TCF12 might play a role in controlling the proliferation of neural stem cells and progenitor cells. TCF12-TWIST1 (twist family bHLH transcription factor 1) heterodimers is required for the development of normal coronal suture. Mutations in the TCF12 heterodimer causes coronal craniosynostosis. TCF12 is critically required for regulating human mesodermal and hematopoietic specification in the early development. Mutations in TCF12 affects the transcriptional activity and leads to anaplastic oligodendroglioma, a rare brain tumor.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
联系
The action of this antibody can be blocked using blocking peptide SBP3500566.
外形
Supplied in PBS with 0.02% sodium azide.
相关产品
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Mutations in TCF12, encoding a basic helix-loop-helix partner of TWIST1, are a frequent cause of coronal craniosynostosis
Sharma VP, et al.
Nature Genetics, 45(3), 304-304 (2013)
TCF-1 and HEB cooperate to establish the epigenetic and transcription profiles of CD4+ CD8+ thymocytes
Emmanuel AO, et al.
Nature Immunology, 6(3), 1-1 (2018)
Expression of the bHLH transcription factor Tcf12 (ME1) gene is linked to the expansion of precursor cell populations during neurogenesis
Uittenbogaard M and Chiaramello A
Gene Expression Patterns, 1(2), 115-121 (2002)
Targeted Disruption of TCF12 Reveals HEB as Essential in Human Mesodermal Specification and Hematopoiesis
Li Y, et al.
Stem Cell Reports, 9(3), 779-795 (2017)
Secreted heat shock protein 90 alpha (HSP90 alpha) induces nuclear factor-kappaB-mediated TCF12 protein expression to down-regulate E-cadherin and to enhance colorectal cancer cell migration and invasion
Chen WS, et al.
The Journal of Biological Chemistry, 288(13), 9001-9010 (2013)
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