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生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
形式
buffered aqueous solution
分子量
predicted mol wt 46 kDa
种属反应性
mouse, human, rat
技术
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
mouse ... Casp12(12364)
一般描述
Caspase-12 (CASP12) is an immunomodulatory factor, that is present in the cytoplasmic side of the ER (endoplasmic reticulum). It is upregulated highly in muscle, liver and kidney.
免疫原
a synthetic peptide corresponding to amino acids within the small cleavage product of murine caspase-12.
生化/生理作用
Caspase-12 (CASP12) plays an important role in endoplasmic reticulum (ER)-related apoptosis. It moderates hepatocyte apoptosis prompted by carbon tetrachloride. Lack of caspase-12 (CASP12) increases cytokine responses.
联系
The action of this antibody can be blocked using blocking peptide SBP3197.
外形
Solution in phosphate buffered saline containing 0.02% sodium azide
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Caspase-12 mediates carbon tetrachloride-induced hepatocyte apoptosis in mice
Liu H, et al.
World Journal of Gastroenterology, 20(48), 18189-18198 (2014)
Caspase-12 deficiency enhances cytokine responses but does not protect against lethal Plasmodium yoelii 17XL infection
Miu J, et al.
Parasite Immunology, 32(11-12), 773-778 (2010)
The resveratrol attenuates ethanol-induced hepatocyte apoptosis via inhibiting ER-related caspase-12 activation and PDE activity in vitro
Liu LQ, et al.
Alcoholism, Clinical and Experimental Research, 38(3), 683-693 (2014)
Caspase-12, but Not Caspase-11, Inhibits Obesity and Insulin Resistance
Skeldon AM, et al.
Journal of Immunology, 196(1), 437-447 (2016)
Juan Carlos Gómora-García et al.
Cell death discovery, 7(1), 131-131 (2021-06-05)
Altered protein homeostasis is associated with neurodegenerative diseases and acute brain injury induced under energy depletion conditions such as ischemia. The accumulation of damaged or unfolded proteins triggers the unfolded protein response (UPR), which can act as a homeostatic response
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