HPA002807
Anti-MFGE8 antibody produced in rabbit
Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
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所有图片(7)
MFG-E8 Antibody - Anti-MFGE8 antibody produced in rabbit, Mfg-E8 Antibody, Anti-Breast epithelial antigen BA46 antibody produced in rabbit, Anti-HMFG antibody produced in rabbit, Anti-Lactadherin precursor antibody produced in rabbit, Anti-MFG-E8 antibody produced in rabbit, Anti-MFGM antibody produced in rabbit, Anti-Milk fat globule-EGF factor 8 antibody produced in rabbit
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生物来源
rabbit
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
产品线
Prestige Antibodies® Powered by Atlas Antibodies
形式
buffered aqueous glycerol solution
种属反应性
human
增强验证
orthogonal RNAseq
recombinant expression
Learn more about Antibody Enhanced Validation
技术
immunoblotting: 0.04-0.4 μg/mL
immunofluorescence: 0.25-2 μg/mL
immunohistochemistry: 1:500-1:1000
免疫原序列
LKNNSIPDKQITASSSYKTWGLHLFSWNPSYARLDKQGNFNAWVAGSYGNDQWLQVDLGSSKEVTGIITQGARNFGSVQFVASYKVAYSNDSANWTEYQDPRTGSSKIFPGNWDNHSHKKNLFETPILARYVRILPVAWHNRIALRLEL
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... MFGE8(4240)
一般描述
MFGE8 (milk fat globule-EGF factor 8 protein) is a ~53kDa plasma membrane glycoprotein that is generated at the bud from the apical surface of mammary epithelial cells during lactation. It is composed of two specific functional domains: an N-terminal domain with two epidermal growth factor (EGF) repeats and a C-terminal domain with two Discoidin/F5/8C domains for binding of anionic phospholipids and/or extracellular matrices.
MFGE8 is mapped to human chromosome 15q26.1.
免疫原
Lactadherin precursor recombinant protein epitope signature tag (PrEST)
应用
Anti-MFGE8 antibody produced in rabbit has been used in immunofluorescence.
Anti-MFGE8 antibody produced in rabbit, a Prestige Antibody, is developed and validated by the Human Protein Atlas (HPA) project . Each antibody is tested by immunohistochemistry against hundreds of normal and disease tissues. These images can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. The antibodies are also tested using immunofluorescence and western blotting. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
生化/生理作用
MFGE8 (milk fat globule-EGF factor 8) protein is involved in wide range of cellular interactions such as phagocytosis of apoptotic lymphocytes and other apoptotic cells, cell adhesion of sperm and the egg coat, intestinal mucosa repair, mammary gland branching morphogenesis, angiogenesis etc. It is potentially involved in different stages of sperm maturation and fertilization mechanism. It accelerates the engulfment of apoptotic carcinoma cells by living carcinoma cells which in turn promotes tumor growth.
特点和优势
Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.
Every Prestige Antibody is tested in the following ways:
Every Prestige Antibody is tested in the following ways:
- IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
- Protein array of 364 human recombinant protein fragments.
联系
Corresponding Antigen APREST77458
外形
Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide
法律信息
Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
Journal of proteomics, 82, 141-154 (2013-03-06)
Milk protein expression in healthy cows and cows with mastitis will provide information important for the dairy food industry and immune function in the mammary gland. To facilitate protein discovery, milk was fractioned into whey, milk fat globule membranes (MFGM)
PloS one, 15(2), e0229606-e0229606 (2020-02-29)
Extracellular vesicles (EVs) such as exosomes are key regulators of intercellular communication that can be found in almost all bio fluids. Although studies in the last decade have made great headway in discerning the role of EVs in many physiological
Mutation Identification for Epilepsy in the US Hispanic Population Using Whole-Exome-Sequencing
Journal of Cell Biology and Cell Metabolism, 3(011) (2016)
Journal of proteomics, 75(5), 1486-1492 (2011-12-02)
Exosomes are 40-100 nm membrane vesicles of endocytic origin, secreted by cells and are found in biological fluids including milk. These exosomes are extracellular organelles important in intracellular communication, and immune function. Therefore, the proteome of bovine milk exosomes may
BMC genomics, 23(1), 189-189 (2022-03-09)
Subclinical mastitis, the inflammation of the mammary gland lacking clinical symptoms, is one of the most prevalent and costly diseases in dairy farming worldwide. Milk microRNAs (miRNAs) encapsulated in extracellular vesicles (EVs) have been proposed as potential biomarkers of different
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