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G2879

Sigma-Aldrich

Glycine hydrochloride

≥99% (HPLC)

Synonym(s):

Aminoacetic acid hydrochloride, Glycine HCl, Glycocoll hydrochloride, Aminoacetic acid, Aminoethanoic acid, Glycocoll

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5 G
CN¥508.18
25 G
CN¥2,645.56
50 G
CN¥4,603.87

CN¥508.18

List PriceCN¥846.97Save 40%

Available to ship onApril 17, 2025Details

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5 G
CN¥508.18
25 G
CN¥2,645.56
50 G
CN¥4,603.87

About This Item

Linear Formula:
H2NCH2CO2H · HCl
CAS Number:
6000-43-7
Molecular Weight:
111.53
EC Number:
227-841-8
MDL number:
MFCD00012872
UNSPSC Code:
12352209
eCl@ss:
32160406
PubChem Substance ID:
24895108
NACRES:
NA.32

CN¥508.18

List PriceCN¥846.97Save 40%

Available to ship onApril 17, 2025Details

Request a Bulk Order

Quality Level

300

Assay

≥99% (HPLC)

form

powder

mol wt

111.53

storage condition

(Tightly closed Dry)

concentration

≤100%

technique(s)

immunohistochemistry: suitable

mp

176-180 °C (lit.)

solubility

water: 0.5 g/mL, clear, colorless

storage temp.

room temp

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1 of 4

This Item
154903PHR1372439193
Methanol UHPLC, suitable for mass spectrometry (MS)

900688

Methanol

Methanol ACS spectrophotometric grade, ≥99.9%

154903

Methanol

Methanol Pharmaceutical Secondary Standard; Certified Reference Material

PHR1372

Methanol

Methanol suitable for HPLC, gradient grade, suitable as ACS-grade LC reagent, ≥99.9%

439193

Methanol

assay

≥99.92%

assay

≥99.9%

assay

-

assay

≥99.9%

application(s)

food and beverages

application(s)

food and beverages

application(s)

pharmaceutical (small molecule)

application(s)

food and beverages

technique(s)

UHPLC: suitable, mass spectrometry (MS): suitable

technique(s)

UV/Vis spectroscopy: suitable

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

HPLC: suitable

form

liquid

form

liquid

form

-

form

liquid

vapor density

1.11 (vs air)

vapor density

1.11 (vs air)

vapor density

1.11 (vs air)

vapor density

1.11 (vs air)

General description

Research area: Neuroscience

Application

Glycine hydrochloride has been used as a component of Ag (silver)-stripping buffer for multiplex immunohistochemistry in mice tissues.[1]
Glycine hydrochloride has been used:
  • in the preparation of glycine-HCl buffer[2]
  • to elute serum immunoglobulins (IgGs) from the beads in order to check for the complete enrichment of core- and site-specific antibodies[3]
  • to regenerate the sensor to elute the bound C-reactive protein (CRP)[4]

Biochem/physiol Actions

Glycine acts on receptors which bring out an enhanced chloride conductance. It shows highest concentrations in the spinal cord as compared to elsewhere in the brain. However, it interacts with and allostericaly activates the excitatory receptor N-methyl-D-aspartate (NMDA), thus, resulting in excitatory transmission in brain.[5][6]
Glycine comprises a single carbon molecule, that is attached to the amino and a carboxyl group.[7] Glycine hydrochloride (Gly·HCl) is capable of liquifying native chitosan and also helps in the preparation of regenerated chitosan membrane.[8] It can serve as an osmoprotectant. Glycine can act as a flexible link in proteins and can also allow the formation of helices.[7] Free glycine may have a protecting role in tissues against ischemia, hypoxia, and reperfusion.[7]Glycine has been studied as a potential treatment for sepsis, arthritis, adult respiratory distress syndrome, and other inflammatory diseases.[9]
Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.

related product

Product No.
Description
Pricing

Pictograms

Corrosion
GHS05

Signal Word

Danger

Hazard Statements

H314

Hazard Classifications

Eye Dam. 1 - Skin Corr. 1

Storage Class Code

8A - Combustible corrosive hazardous materials

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves
  • Specification Sheet

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    Certificates of Analysis (COA)

    Lot/Batch Number
    0000438995
    0000438994
    0000438993
    0000438993
    0000438994

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    Coupling of HIV-1 gp120-derived Core Protein to Paramagnetic Beads and Adsorption Assays
    Ingale J and Wyatt RT
    Bio-protocol, 5(20) (2015)
    Zipei Feng et al.
    Journal of immunology (Baltimore, Md. : 1950), 196(9), 3943-3950 (2016-03-20)
    Recent advances in multiplex immunohistochemistry techniques allow for quantitative, spatial identification of multiple immune parameters for enhanced diagnostic and prognostic insight. However, applying such techniques to murine fixed tissues, particularly sensitive epitopes, such as CD4, CD8α, and CD19, has been
    M D Wheeler et al.
    Cellular and molecular life sciences : CMLS, 56(9-10), 843-856 (2001-02-24)
    The mechanism of the immunosuppressive effects of glycine and its pathophysiological applications are discussed in this review. Glycine has been well characterized in spinal cord as an inhibitory neurotransmitter which activates a glycine-gated chloride channel (GlyR) expressed in postsynaptic membranes.
    A comparative study on the chitosan membranes prepared from glycine hydrochloride and acetic acid
    Ma B, et al.
    Carbohydrate Polymers, 91(2), 477-482 (2013)
    Particle-Based Microfluidic Quartz Crystal Microbalance (QCM) Biosensing Utilizing Mass Amplification and Magnetic Bead Convection
    Thies JW, et al.
    Micromachines, 4-4 (2019)
    View All Related Papers

    Protocols

    Stripping and Reprobing Western Blotting Membranes

    This page shows and discusses three protocols for stripping and reprobing a western blot membrane.

    Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

    Contact Technical Service