PDHA1
pyruvate dehydrogenase (lipoamide) alpha 1
别名:
PDHA, PDHCE1A, PHE1A
物种:
Human PDHA1 (5160), Mouse Pdha1 (18597), Rat Pdha1 (29554), chicken PDHA1 (418610), Domestic Rabbit PDHA1 (100357349), sheep PDHA1 (101110118), domestic cat PDHA1 (101080765), dog PDHA1 (480858), domestic guinea pig Pdha1 (100735725), naked mole-rat Pdha1 (101716937)
UniProtKB ID:
基因ID:
- Human(5160) Summary: The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 alpha 1 subunit containing the E1 active site, and plays a key role in the function of the PDH complex. Mutations in this gene are associated with pyruvate dehydrogenase E1-alpha deficiency and X-linked Leigh syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010]
- Mouse(18597) pyruvate dehydrogenase E1 alpha 1
- Rat(29554) pyruvate dehydrogenase (lipoamide) alpha 1
- chicken(418610) pyruvate dehydrogenase (lipoamide) alpha 1
- Domestic Rabbit(100357349) pyruvate dehydrogenase (lipoamide) alpha 1
- sheep(101110118) pyruvate dehydrogenase (lipoamide) alpha 1
- domestic cat(101080765) pyruvate dehydrogenase (lipoamide) alpha 1
- dog(480858) pyruvate dehydrogenase (lipoamide) alpha 1
- domestic guinea pig(100735725) pyruvate dehydrogenase (lipoamide) alpha 1
- naked mole-rat(101716937) pyruvate dehydrogenase (lipoamide) alpha 1
- cow(407109) pyruvate dehydrogenase (lipoamide) alpha 1
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Antibodies
货号
说明
物种反应性
应用
磷酸化-PDHE1-A I 型 (Ser293) 抗体, from rabbit, purified by affinity chromatography,
物种反应性
bovine, human, mouse, primate, rat, zebrafish
应用
immunocytochemistry
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
磷酸化PDHE1-A I型（Ser300）抗体, from rabbit, purified by affinity chromatography,
物种反应性
xenopus, bovine, human, mouse, rat, zebrafish
应用
immunocytochemistry
western blot
western blot
Anti-PDH, serum, from rabbit,
物种反应性
human, mouse
应用
immunocytochemistry
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot
Anti-p-PDHA1-Ser232 Antibody, clone 2D5 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
物种反应性
bovine, horse, human, monkey, mouse, rat, sheep
应用
immunocytochemistry
immunohistochemistry
inhibition assay
western blot
immunohistochemistry
inhibition assay
western blot
Anti-PDHA1 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
物种反应性
human
应用
western blot