MAP3K5
mitogen-activated protein kinase kinase kinase 5
别名:
ASK1, MAPKKK5, MEKK5
物种:
Human MAP3K5 (4217), Mouse Map3k5 (26408), Rat Map3k5 (365057), chicken MAP3K5 (421688), domestic cat MAP3K5 (101082912), dog MAP3K5 (476215), Zebrafish map3k5 (555703), sheep MAP3K5 (101121018), cow MAP3K5 (537380), Horse MAP3K5 (100073186) ...展开
UniProtKB ID:
基因ID:
- Human(4217) Summary: Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK. [provided by RefSeq, Jul 2008]
- Mouse(26408) mitogen-activated protein kinase kinase kinase 5
- Rat(365057) mitogen-activated protein kinase kinase kinase 5
- chicken(421688) mitogen-activated protein kinase kinase kinase 5
- domestic cat(101082912) mitogen-activated protein kinase kinase kinase 5
- dog(476215) mitogen-activated protein kinase kinase kinase 5
- Zebrafish(555703) mitogen-activated protein kinase kinase kinase 5
- sheep(101121018) mitogen-activated protein kinase kinase kinase 5
- cow(537380) mitogen-activated protein kinase kinase kinase 5
- Horse(100073186) mitogen-activated protein kinase kinase kinase 5
- naked mole-rat(101712051) mitogen-activated protein kinase kinase kinase 5
- domestic guinea pig(100722979) mitogen-activated protein kinase kinase kinase 5
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Antibodies
货号
说明
物种反应性
应用
Anti-phospho-ASK1 (pSer966) antibody produced in rabbit, affinity isolated antibody,
物种反应性
human, mouse, rat
应用
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-phospho-ASK1 (pSer83) antibody produced in rabbit, affinity isolated antibody,
物种反应性
human, mouse, rat
应用
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-MAP3K5 (Ab-83) antibody produced in rabbit, affinity isolated antibody,
物种反应性
human
应用
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-MAP3K5 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
物种反应性
human
应用
immunohistochemistry
Anti-ASK1 antibody produced in rabbit, affinity isolated antibody,
物种反应性
human, mouse, rat
应用
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot