推荐产品
产品名称
N-乙酰基-L-半胱氨酸, Vetec™, reagent grade, 98%
等级
reagent grade
产品线
Vetec™
方案
98%
表单
powder
颜色
white to off-white
mp
106-108 °C (lit.)
应用
cell analysis
储存温度
2-8°C
SMILES字符串
CC(=O)N[C@@H](CS)C(O)=O
InChI
1S/C5H9NO3S/c1-3(7)6-4(2-10)5(8)9/h4,10H,2H2,1H3,(H,6,7)(H,8,9)/t4-/m0/s1
InChI key
PWKSKIMOESPYIA-BYPYZUCNSA-N
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应用
- 抗氧化检测方法开发：N-乙酰-L-半胱氨酸(NAC)参与CYP3A介导的芦竹碱细胞的代谢激活和毒性评估，反应它在氧化应激生化分析中的重要性，是IVD试剂开发的重要参考因素(Gao et al., 2024)。
- 细胞分化和NF-κB抑制：本文中，乙酰半胱氨酸又有不同的作用，它可诱导氧化应激和抑制NF-κB通路，对急性髓系白血病(AML)治疗细胞的分化起重要作用。表明乙酰半胱氨酸可用于癌症治疗和研究的临床诊断试剂中(Silva et al., 2024)。
- 肝损伤治疗：用乙酰半胱氨酸缓解对乙酰氨基酚过量引起的肝损伤，体现其临床应用潜力和开发IVD治疗检测产品的用途(Chen et al., 2024)。
- 提高癌症疗效：乙酰半胱氨酸用于联合治疗胃后(posterior gastric)腹膜假黏液瘤，可作为生化药物提高癌症治疗功效，适于诊断和治疗应用(Sun et al., 2024)。
- 细胞周期和自噬调节：乙酰半胱氨酸可与1-甲氧基异芸苔素(Methoxyisobrassinin)在卵巢癌细胞中相互作用调节细胞周期、凋亡和自噬，体现它开发生物标志物检测等IVD产品的作用(Zigová et al., 2024)。
生化/生理作用
抗氧化剂和黏液溶解剂(mucolytic agent)。增加细胞池的自由基清除剂。 据报道可防止神经细胞凋亡，但会诱导平滑肌细胞凋亡。抑制HIV复制。可作为微粒体谷胱甘肽转移酶的底物。
法律信息
Vetec is a trademark of Merck KGaA, Darmstadt, Germany
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2
储存分类代码
13 - Non Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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