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安全信息

1225703

USP

阿霉素 盐酸盐

United States Pharmacopeia (USP) Reference Standard

别名:

DOX, 多柔比星® 盐酸盐, 羟基柔红霉素 盐酸盐

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1 EA
CN¥1,432.73

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1 EA
CN¥1,432.73

About This Item

经验公式（希尔记法）:
C27H29NO11 · HCl
CAS号:
25316-40-9
分子量:
579.98
Beilstein:
4229251
MDL编号:
MFCD00077757
UNSPSC代码:
41116107
PubChem化学物质编号:
329749677
NACRES:
NA.24

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等级

pharmaceutical primary standard

API类

doxorubicin

制造商/商品名称

USP

mp

216 °C (dec.) (lit.)

应用

pharmaceutical (small molecule)

包装形式

neat

储存温度

−20°C

SMILES字符串

Cl[H].COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(=O)CO

InChI

1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3;1H/t10-,13-,15-,17-,22+,27-;/m0./s1

InChI key

MWWSFMDVAYGXBV-RUELKSSGSA-N

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D-Ribulose 1,5-Diphosphate Carboxylase from spinach partially purified powder, 0.01-0.1 unit/mg solid

R8000

D-Ribulose 1,5-Diphosphate Carboxylase from spinach

Phosphoriboisomerase from spinach Type I, partially purified powder, ≥40 units/mg protein (biuret)

P9752

Phosphoriboisomerase from spinach

Ferredoxin-NADP+ Reductase from Spinacia oleracea (spinach) lyophilized powder, ≥15 units/mg solid, secondary activity: ≥10 units/mg solid NADPH diaphorase

F0628

Ferredoxin-NADP+ Reductase from Spinacia oleracea (spinach)

Ferredoxin from Spinacia oleracea (spinach) lyophilized powder, Ferredoxin ≥15 wt. %

F3013

Ferredoxin from Spinacia oleracea (spinach)

specific activity

0.01-0.1 unit/mg solid

specific activity

≥40 units/mg protein (biuret)

specific activity

≥15 units/mg solid

specific activity

-

biological source

spinach

biological source

spinach

biological source

-

biological source

spinach (Spinacia oleracea)

form

partially purified powder

form

partially purified powder

form

lyophilized powder

form

lyophilized powder

mol wt

557 kDa

mol wt

-

mol wt

-

mol wt

-

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

应用

Doxorubicin hydrochloride USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Doxorubicin Hydrochloride Injection
  • Doxorubicin Hydrochloride for Injection
  • Epirubicin Hydrochloride
  • Epirubicin Hydrochloride Injection

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

其他说明

Sales restrictions may apply.

象形图

Health hazardExclamation mark
GHS08,GHS07

警示用语：

Danger

危险分类

Acute Tox. 4 Oral - Carc. 1B - Muta. 1B - Repr. 1B

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

监管及禁止进口产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Doxorubicin Hydrochloride Injection
United States Pharmacopeia, 42(4), 1514-1514 (2022)
Doxorubicin Hydrochloride for Injection
United States Pharmacopeia, 40(4), 1516-1516 (2022)
Doxorubicin Hydrochloride
United States Pharmacopeia, 40(3), 1512-1512 (2020)
C Main et al.
Health technology assessment (Winchester, England), 10(9), 1-132 (2006-03-21)
To examine the clinical effectiveness and cost-effectiveness of intravenous formulations of topotecan monotherapy, pegylated liposomal doxorubicin hydorocholoride (PLDH) monotherapy and paclitaxel used alone or in combination with a platinum-based compound for the second-line or subsequent treatment of advanced ovarian cancer.
Rafael Luiz Pereira et al.
Disease models & mechanisms, 7(6), 701-710 (2014-04-20)
Focal and segmental glomerulosclerosis (FSGS) is one of the most important renal diseases related to end-stage renal failure. Bradykinin has been implicated in the pathogenesis of renal inflammation, whereas the role of its receptor 2 (B2RBK; also known as BDKRB2)
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