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Merck
CN
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文件

U1006

Sigma-Aldrich

尿苷-5′-三磷酸酯 三钠盐 溶液

HPLC purified, aqueous solution for RNA polymerase transcription

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别名:
UTP
MDL编号:
MFCD00044310
UNSPSC代码:
41106305
PubChem化学物质编号:
24900622
NACRES:
NA.52

生物来源

yeast (Candida Utilis)

质量水平

300

检测方案

≥95 (HPLC)

形式

liquid

浓度

100 mM in H2O (adjusted to pH 7 with Trizma®
base)

颜色

colorless

异质活性

DNase and RNase, none detected

运输

dry ice

储存温度

−20°C

SMILES字符串

[Na+].[Na+].[Na+].O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP([O-])(=O)OP([O-])(=O)OP(O)([O-])=O)N2C=CC(=O)NC2=O

InChI

1S/C9H15N2O15P3.3Na/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18;;;/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18);;;/q;3*+1/p-3/t4-,6-,7-,8-;;;/m1.../s1

InChI key

MMJGIWFJVDOPJF-LLWADOMFSA-K

基因信息

human ... P2RY2(5029)
rat ... P2ry2(29597)

相关类别

应用

尿苷5′-三磷酸三钠盐溶液已用于增加大鼠原代气管上皮细胞中细胞内Ca2+水平。它还用作核苷酸底物，以分析MutT同源物1（MTH1）的活性。

生化/生理作用

UTP参与RNA合成，在转录过程中具有至关重要的作用。它与糖原合成、蛋白质糖基化和膜磷脂生物合成有关。UTP 参与 ATP 的生产，而 ATP 对代谢反应至关重要。
尿苷5′-三磷酸（UTP）会在神经损伤时释放，并用作存在于雪旺细胞表面的嘌呤P2Y2受体的激动剂。

法律信息

Trizma is a registered trademark of Merck KGaA, Darmstadt, Germany

相关产品

产品编号
说明
价格

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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Aloa Lamarca et al.
PloS one, 9(6), e98998-e98998 (2014-06-07)
In response to peripheral nerve injury, Schwann cells adopt a migratory phenotype and modify the extracellular matrix to make it permissive for cell migration and axonal re-growth. Uridine 5'-triphosphate (UTP) and other nucleotides are released during nerve injury and activate
Uridine metabolism and its role in glucose, lipid, and amino acid homeostasis
Zhang Y, et al.
BioMed Research International, 2020 (2020)
Biochemistry of uridine in plasma
Yamamoto T, et al.
Clinica Chimica Acta; International Journal of Clinical Chemistry, 412(19-20), 1712-1724 (2011)
Ann-Sofie Jemth et al.
Nucleic acids research, 46(20), 10888-10904 (2018-10-12)
Nucleotides in the free pool are more susceptible to nonenzymatic methylation than those protected in the DNA double helix. Methylated nucleotides like O6-methyl-dGTP can be mutagenic and toxic if incorporated into DNA. Removal of methylated nucleotides from the nucleotide pool
Anne Hahn et al.
Physiological reports, 5(12) (2017-06-24)
Transport of water and electrolytes in airway epithelia involves chloride-selective ion channels, which are controlled either by cytosolic Ca2+ or by cAMP The contributions of the two pathways to chloride transport differ among vertebrate species. Because rats are becoming more

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