SFTPD human

SFTPD (surfactant protein D) is a Ca2⁺-binding, large multimeric hydrophilic protein, which is produced by type II pneumocytes and club cells. It lines the alveolar epithelium. It is a member of collectins (collagen-containing C-type lectins) which are involved in innate responses.

SFTPD, as known as Surfactant pulmonary-associated protein D, is a member of the collectin family of C-type lectins that is synthesized in many tissues including respiratory epithelial cells in the lung, and contains one C-type lectin domain and one collagen-like domain. It is humoral molecules of the innate immune system, and is considered a functional candidate in chronic periodontitis. It is also involved in the development of acute and chronic inflammation of the lung. Several human lung diseases are characterized by decreased levels of bronchoalveolar SFTPD. Recombinant human SFTPD protein, fused to His-tag at N-terminus, was expressed in E.coli.
SFTPD (surfactant protein D) encodes an extracellular soluble protein that is expressed in the mucosal membrane. The SFTPD gene is mapped to human chromosome 10q22.3.

SFTPD (surfactant protein D) protein is thought to decrease inflammatory responses in alveolar macrophages and oxidant production, and increase apoptotic cell clearance. Elevated serum levels of this protein function as biomarker for susceptibility to COPD (chronic obstructive pulmonary disease). It is involved in the pathogenesis of COPD, and certain polymorphisms in this gene are linked with changes in its serum level and lung function. In human bronchoalveolar lavage, SFTPD is the predominant protein involved in antiviral response against seasonal strains of influenza A virus (IAV). Studies in mice show that the neck and carbohydrate recognition domain (NCRD) of this protein confers protection against allergy and respiratory syncytial virus infection. Variations in this gene are linked with lung function measures in context of tobacco smoking. Hence, this protein has potential as a biomarker for subclinical tobacco smoke-induced lung damage.

1 mg/mL in 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, and 0.4 M Urea.