SRP6343
SFTPD human
recombinant, expressed in E. coli, ≥80% (SDS-PAGE)
Synonym(s):
COLEC7, PSP-D, Pulmonary surfactant-associated protein D precursor, SFTP4, SP-D
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About This Item
UNSPSC Code:
12352202
NACRES:
NA.32
biological source
human
recombinant
expressed in E. coli
Assay
≥80% (SDS-PAGE)
form
liquid
mol wt
18.9 kDa (175 aa, 224-375 aa + His Tag)
packaging
pkg of 100 μg
concentration
1 mg/mL
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... SFTPD(6441)
General description
SFTPD (surfactant protein D) is a Ca2+-binding, large multimeric hydrophilic protein, which is produced by type II pneumocytes and club cells. It lines the alveolar epithelium. It is a member of collectins (collagen-containing C-type lectins) which are involved in innate responses.
SFTPD, as known as Surfactant pulmonary-associated protein D, is a member of the collectin family of C-type lectins that is synthesized in many tissues including respiratory epithelial cells in the lung, and contains one C-type lectin domain and one collagen-like domain. It is humoral molecules of the innate immune system, and is considered a functional candidate in chronic periodontitis. It is also involved in the development of acute and chronic inflammation of the lung. Several human lung diseases are characterized by decreased levels of bronchoalveolar SFTPD. Recombinant human SFTPD protein, fused to His-tag at N-terminus, was expressed in E.coli.
SFTPD (surfactant protein D) encodes an extracellular soluble protein that is expressed in the mucosal membrane. The SFTPD gene is mapped to human chromosome 10q22.3.
SFTPD (surfactant protein D) encodes an extracellular soluble protein that is expressed in the mucosal membrane. The SFTPD gene is mapped to human chromosome 10q22.3.
Biochem/physiol Actions
SFTPD (surfactant protein D) protein is thought to decrease inflammatory responses in alveolar macrophages and oxidant production, and increase apoptotic cell clearance. Elevated serum levels of this protein function as biomarker for susceptibility to COPD (chronic obstructive pulmonary disease). It is involved in the pathogenesis of COPD, and certain polymorphisms in this gene are linked with changes in its serum level and lung function. In human bronchoalveolar lavage, SFTPD is the predominant protein involved in antiviral response against seasonal strains of influenza A virus (IAV). Studies in mice show that the neck and carbohydrate recognition domain (NCRD) of this protein confers protection against allergy and respiratory syncytial virus infection. Variations in this gene are linked with lung function measures in context of tobacco smoking. Hence, this protein has potential as a biomarker for subclinical tobacco smoke-induced lung damage.
Physical form
1 mg/mL in 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, and 0.4 M Urea.
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Surfactant protein D is a candidate biomarker for subclinical tobacco smoke-induced lung damage.
Johansson SL, et al.
American Journal of Physiology. Lung Cellular and Molecular Physiology, 306(9), L887-L895 (2014)
Christian A Ruge et al.
PloS one, 7(7), e40775-e40775 (2012-07-18)
The peripheral lungs are a potential entrance portal for nanoparticles into the human body due to their large surface area. The fact that nanoparticles can be deposited in the alveolar region of the lungs is of interest for pulmonary drug
Kun Cao et al.
Journal of inorganic biochemistry, 182, 113-123 (2018-02-20)
Iron is an essential element for almost all bacteria. The iron ATP-binding cassette (ABC) transporters located on the cell membrane affects bacterial virulence and infection. Although a variety of Fe3+-transporters have been found in bacteria, their evolutionary processes are rarely
Ryuta Saka et al.
Pediatric surgery international, 32(1), 59-63 (2015-10-30)
Necrotizing enterocolitis (NEC) is a devastating inflammatory disease of preterm infants that may depend on overexpression of toll-like receptor-4 (TLR4) in the immature intestine. Surfactant protein (SP)-D is a member of the collectin family and plays an important role in
Tremor?ataxia with central hypomyelination (TACH) leukodystrophy maps to chromosome 10q22. 3?10q23. 31.
Bernard G, et al.
Neurogenetics, 11(4), 457-464 (2010)
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