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SML0652

Sigma-Aldrich

IOX2

≥98% (HPLC)

别名:

JICL38, N-[[1,2-Dihydro-4-hydroxy-2-oxo-1-(phenylmethyl)-3-quinolinyl]carbonyl]-glycine, N-[[4-Hydroxy-2-oxo-1-(phenylmethyl)-1,2-dihydro-3-quinolinyl]carbonyl]glycine

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100 MG
CN¥529.62
500 MG
CN¥1,878.18
1 G
CN¥2,610.59
5 G
CN¥10,455.30

CN¥529.62

国内现货，预计发货时间April 23, 2025详情

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100 MG
CN¥529.62
500 MG
CN¥1,878.18
1 G
CN¥2,610.59
5 G
CN¥10,455.30

About This Item

经验公式（希尔记法）:
C19H16N2O5
CAS号:
931398-72-0
分子量:
352.34
MDL编号:
MFCD22580424
UNSPSC代码:
12352200
PubChem化学物质编号:
329825575
NACRES:
NA.77

CN¥529.62

国内现货，预计发货时间April 23, 2025详情

获取大包装报价

质量水平

100

方案

≥98% (HPLC)

表单

powder

颜色

white to beige

溶解性

DMSO: 5 mg/mL, clear (warmed)

储存温度

2-8°C

SMILES字符串

OC(C1=C(N2CC3=CC=CC=C3)C=CC=C1)=C(C(NCC(O)=O)=O)C2=O

InChI

1S/C19H16N2O5/c22-15(23)10-20-18(25)16-17(24)13-8-4-5-9-14(13)21(19(16)26)11-12-6-2-1-3-7-12/h1-9,24H,10-11H2,(H,20,25)(H,22,23)

InChI key

CAOSCCRYLYQBES-UHFFFAOYSA-N

相关类别

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此商品
53919U53918U53910U
Ascentis® Express RP-Amide, 2.7 μm HPLC Column 2.7 μm particle size, L × I.D. 15 cm × 2.1 mm

53914U

Ascentis® Express RP-Amide, 2.7 μm HPLC Column

Ascentis® Express RP-Amide, 2.7 μm HPLC Column 2.7 μm particle size, L × I.D. 15 cm × 3 mm

53919U

Ascentis® Express RP-Amide, 2.7 μm HPLC Column

Ascentis® Express RP-Amide, 2.7 μm HPLC Column 2.7 μm particle size, L × I.D. 10 cm × 3 mm

53918U

Ascentis® Express RP-Amide, 2.7 μm HPLC Column

Ascentis® Express RP-Amide, 2.7 μm HPLC Column 2.7 μm particle size, L × I.D. 3 cm × 2.1 mm

53910U

Ascentis® Express RP-Amide, 2.7 μm HPLC Column

particle size

2.7 μm

particle size

2.7 μm

particle size

2.7 μm

particle size

2.7 μm

matrix active group

amide, alkyl phase

matrix active group

amide, alkyl phase

matrix active group

amide, alkyl phase

matrix active group

amide, alkyl phase

matrix

Fused-Core® particle platform, superficially porous particle

matrix

Fused-Core® particle platform, superficially porous particle

matrix

Fused-Core® particle platform, superficially porous particle

matrix

Fused-Core® particle platform, superficially porous particle

technique(s)

HPLC: suitable, UHPLC-MS: suitable, LC/MS: suitable, UHPLC: suitable

technique(s)

HPLC: suitable, LC/MS: suitable, UHPLC-MS: suitable, UHPLC: suitable

technique(s)

HPLC: suitable, LC/MS: suitable, UHPLC-MS: suitable, UHPLC: suitable

technique(s)

HPLC: suitable, LC/MS: suitable, UHPLC-MS: suitable, UHPLC: suitable

pore size

90 Å

pore size

90 Å

pore size

90 Å

pore size

90 Å

应用

IOX2 has been used as PHD inhibitor to induce pseudo-hypoxia.[1]

生化/生理作用

IOX2 is selective and potent inhibitor of prolyl hydroxylases (PHD).
IOX2 is selective and potent inhibitor of prolyl hydroxylases (PHD). Stabilization of HIF-1R through inhibition of PHD has been examined as a potential treatment for ischemic diseases including anemia, myocardial infarction, and stroke. IOX2 is a selective inhibitor of the hypoxia inducible factor (HIF) prolyl-hydroxylases (PHD) that exhibits up-regulation of HIF1a in zebrafish. For full characterization details, please visit the IOX2 probe summary on the Structural Genomics Consortium (SGC) website.

To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc

特点和优势

IOX2 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC.
This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

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象形图

Skull and crossbones
GHS06

警示用语：

Danger

危险声明

H301

危险分类

Acute Tox. 3 Oral

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

  • 技术规格说明书

    • 历史批次信息供参考:

    分析证书(COA)

    Lot/Batch Number
    0000425651
    0000425648
    0000425648
    0000425651
    0000397125

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    访问文档库

    Resveratrol integrates metabolic and growth effects in PC3 prostate cancer cells-involvement of prolyl hydroxylase and hypoxia inducible factor-1
    Fonseca J, et al.
    Oncology Letters (2018)
    Pieter-Jan Stiers et al.
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 34(2), 333-348 (2018-11-20)
    Tissue engineering holds great promise for bone regenerative medicine, but clinical translation remains challenging. An important factor is the low cell survival after implantation, primarily caused by the lack of functional vasculature at the bone defect. Interestingly, bone development and
    Yuetao Zhao et al.
    Biochemical and biophysical research communications, 517(2), 201-209 (2019-07-25)
    Lung cancer is the most commonly diagnosed cancer and accounts for most cancer-related mortalities worldwide. The high expression of programmed death ligand 1 (PD-L1) is an important factor that promotes immune escape of lung cancer, thus aggravates chemotherapy resistance and
    Hu Peng et al.
    American journal of physiology. Renal physiology, 318(2), F468-F474 (2019-12-17)
    Acute pyelonephritis is frequently associated with metabolic acidosis. We previously reported that metabolic acidosis stimulates expression of hypoxia-inducible factor (HIF)-1α-induced target genes such as stromal derived factor-1 and cathelicidin, an antimicrobial peptide. Since the collecting duct (CD) plays a pivotal
    Deirdre Scully et al.
    Development (Cambridge, England), 143(10), 1742-1752 (2016-05-18)
    Hypoxia is encountered in either pathological or physiological conditions, the latter of which is seen in amniote embryos prior to the commencement of a functional blood circulation. During the hypoxic stage, a large number of neural crest cells arise from
    查看所有相关文献

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