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SML0652

IOX2

Name: IOX2
Brand: SIGMA

≥98% (HPLC)

别名:

JICL38, N-[[1,2-Dihydro-4-hydroxy-2-oxo-1-(phenylmethyl)-3-quinolinyl]carbonyl]-glycine, N-[[4-Hydroxy-2-oxo-1-(phenylmethyl)-1,2-dihydro-3-quinolinyl]carbonyl]glycine

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About This Item

经验公式（希尔记法）:

C₁₉H₁₆N₂O₅

CAS号:

931398-72-0

分子量:

352.34

MDL编号:

MFCD22580424

UNSPSC代码:

12352200

PubChem化学物质编号:

329825575

NACRES:

NA.77

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Sigma-Aldrich

736147

L-Ornithine-¹³C₅ hydrochloride

Sigma-Aldrich

400083

HIF-1 Inhibitor

Sigma-Aldrich

400084

HIF Prolyl Hydroxylase Inhibitor

Sigma-Aldrich

07-224

抗磷酸化-STAT2 (Tyr689) 抗体

Sigma-Aldrich

SCP0004

γ Secretase Inhibitor

Sigma-Aldrich

565789

γ分泌酶抑制剂 XX

Avanti

861809O

油酸-d9

Supelco

S-111

MMB-FUBINACA 溶液

Sigma-Aldrich

SML1046

CHIR99021

Sigma-Aldrich

400093

HIF-PHD抑制剂II，JNJ-42041935

质量水平

100

方案

≥98% (HPLC)

表单

powder

颜色

white to beige

溶解性

DMSO: 5 mg/mL, clear (warmed)

储存温度

2-8°C

SMILES字符串

OC(C1=C(N2CC3=CC=CC=C3)C=CC=C1)=C(C(NCC(O)=O)=O)C2=O

InChI

1S/C19H16N2O5/c22-15(23)10-20-18(25)16-17(24)13-8-4-5-9-14(13)21(19(16)26)11-12-6-2-1-3-7-12/h1-9,24H,10-11H2,(H,20,25)(H,22,23)

InChI key

CAOSCCRYLYQBES-UHFFFAOYSA-N

应用

IOX2 has been used as PHD inhibitor to induce pseudo-hypoxia.

生化/生理作用

IOX2 is selective and potent inhibitor of prolyl hydroxylases (PHD).

IOX2 is selective and potent inhibitor of prolyl hydroxylases (PHD). Stabilization of HIF-1R through inhibition of PHD has been examined as a potential treatment for ischemic diseases including anemia, myocardial infarction, and stroke. IOX2 is a selective inhibitor of the hypoxia inducible factor (HIF) prolyl-hydroxylases (PHD) that exhibits up-regulation of HIF1a in zebrafish. For full characterization details, please visit the IOX2 probe summary on the Structural Genomics Consortium (SGC) website.

To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc

特点和优势

IOX2 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC.

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

警示用语：

Danger

危险声明

H301

预防措施声明

P264 - P270 - P301 + P310 - P405 - P501

危险分类

Acute Tox. 3 Oral

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Inhibition of the Oxygen Sensor PHD2 Enhances Tissue-Engineered Endochondral Bone Formation.

Pieter-Jan Stiers et al.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 34(2), 333-348 (2018-11-20)

Tissue engineering holds great promise for bone regenerative medicine, but clinical translation remains challenging. An important factor is the low cell survival after implantation, primarily caused by the lack of functional vasculature at the bone defect. Interestingly, bone development and

Resveratrol integrates metabolic and growth effects in PC3 prostate cancer cells-involvement of prolyl hydroxylase and hypoxia inducible factor-1

Fonseca J, et al.

Oncology Letters (2018)

Berberine Reverses Hypoxia-induced Chemoresistance in Breast Cancer through the Inhibition of AMPK- HIF-1α.

Yue Pan et al.

International journal of biological sciences, 13(6), 794-803 (2017-06-29)

Breast cancer is the most common type of cancer and the second leading cause of cancer death in American women. Chemoresistance is common and inevitable after a variable period of time. Therefore, chemosensitization is a necessary strategy on drug-resistant breast

Hypoxia promotes production of neural crest cells in the embryonic head.

Deirdre Scully et al.

Development (Cambridge, England), 143(10), 1742-1752 (2016-05-18)

Hypoxia is encountered in either pathological or physiological conditions, the latter of which is seen in amniote embryos prior to the commencement of a functional blood circulation. During the hypoxic stage, a large number of neural crest cells arise from

Acidosis induces antimicrobial peptide expression and resistance to uropathogenic E. coli infection in kidney collecting duct cells via HIF-1α.

Hu Peng et al.

American journal of physiology. Renal physiology, 318(2), F468-F474 (2019-12-17)

Acute pyelonephritis is frequently associated with metabolic acidosis. We previously reported that metabolic acidosis stimulates expression of hypoxia-inducible factor (HIF)-1α-induced target genes such as stromal derived factor-1 and cathelicidin, an antimicrobial peptide. Since the collecting duct (CD) plays a pivotal

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Discover Bioactive Small Molecules for Gene Regulation

We offer a variety of small molecule research tools, such as transcription factor modulators, inhibitors of chromatin modifying enzymes, and agonists/antagonists for target identification and validation in gene regulation research; a selection of these research tools is shown below.

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

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主要文件

IOX2

≥98% (HPLC)

About This Item

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方案

表单

颜色

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储存温度

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InChI

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危险声明

预防措施声明

危险分类

储存分类代码

WGK

闪点(°F)

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分析证书(COA)

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