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SML1410

Sigma-Aldrich

A-366

≥98% (HPLC)

Synonym(s):

5′-Methoxy-6′-[3-(1-pyrrolidinyl)propoxy]-spiro[cyclobutane-1,3′-[3H]indol]-2′-amine

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250 G
CN¥1,000.26
1 KG
CN¥4,616.55

CN¥1,000.26

List priceCN¥1,445.76Save 31%

Available to ship onApril 09, 2025Details


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250 G
CN¥1,000.26
1 KG
CN¥4,616.55

About This Item

Empirical Formula (Hill Notation):
C19H27N3O2
CAS Number:
Molecular Weight:
329.44
MDL number:
UNSPSC Code:
12352202
PubChem Substance ID:
NACRES:
NA.77

CN¥1,000.26

List priceCN¥1,445.76Save 31%

Available to ship onApril 09, 2025Details


Request a Bulk Order

Quality Level

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 10 mg/mL, clear

storage temp.

2-8°C

SMILES string

NC1=NC2=CC(OCCCN3CCCC3)=C(OC)C=C2C14CCC4

InChI

1S/C19H27N3O2/c1-23-16-12-14-15(21-18(20)19(14)6-4-7-19)13-17(16)24-11-5-10-22-8-2-3-9-22/h12-13H,2-11H2,1H3,(H2,20,21)

InChI key

BKCDJTRMYWSXMC-UHFFFAOYSA-N

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Quality Level

200

Quality Level

100

Quality Level

200

Quality Level

100

assay

≥99.9% (GC)

assay

≥99.8% (GC)

assay

≥99.8% (GC)

assay

-

technique(s)

HPLC: suitable

technique(s)

HPLC: suitable

technique(s)

-

technique(s)

-

form

liquid

form

liquid

form

liquid

form

-

vapor pressure

128 hPa ( 20 °C), 97.68 mmHg ( 20 °C), 410 mmHg ( 50 °C)

vapor pressure

128 hPa ( 20 °C), 410 mmHg ( 50 °C), 97.68 mmHg ( 20 °C)

vapor pressure

128 hPa ( 20 °C), 410 mmHg ( 50 °C), 97.68 mmHg ( 20 °C)

vapor pressure

410 mmHg ( 50 °C), 97.68 mmHg ( 20 °C)

Biochem/physiol Actions

A-366 is an SGC chemical probe for G9a/GLP, developed in collaboration with Abbvie. A-366 is a potent, selective inhibitor of the histone methyltransferase G9a. The IC50 values for G9a inhbition in enzymatic and cell based assays are 3.3 and approximately 3 μM, respectively. A-366 has little or no detectable activity against a panel of 21 other methyltransferases. For full characterization details, please visit the A-366 probe summary on the Structural Genomics Consortium (SGC) website.

To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc
A-366 is potent, selective inhibitor of the histone methyltransferase G9a.

Features and Benefits

A-366 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC.
This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Other Notes

A-366 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the A-366 probe summary on the Chemical Probes Portal website.

related product

Product No.
Description
Pricing

Pictograms

Environment

Signal Word

Warning

Hazard Statements

Precautionary Statements

Hazard Classifications

Aquatic Acute 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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