推荐产品
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen 33 kDa
种属反应性
mouse, human, rat
浓度
~1 mg/mL
技术
ELISA: 1:5000
western blot: 1:500-1:1000
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
phosphorylation (pTyr15)
基因信息
human ... CDK5(1020)
一般描述
Cyclin-dependent kinase 5 (CDK5) belongs to the CDKs family. Active CDK5 is present in pancreatic β cells, corneal epithelial cells and monocytes. This gene is mapped to human chromosome 7q36.
免疫原
The antiserum was produced against synthesized peptide derived from human CDK5 around the phosphorylation site of Tyr15.
Immunogen Range: 1-50
Immunogen Range: 1-50
生化/生理作用
Cyclin-dependent kinase 5 (CDK5) controls migration and neuronal plasticity. This protein participates in neuron migration, neurite outgrowth and support and synaptogenesis. It also helps in the development of lymphatic vessels. Suppressing Cdk5 promotes cell death of tumor-initiating cells.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Inhibition of Cdk5 induces cell death of tumor-initiating cells
Mandl MM, et al.
British Journal of Cancer, 116(7), 912-922 (2017)
Biological functions of CDK5 and potential CDK5 targeted clinical treatments
Shupp A, et al.
Oncotarget, 8(10), 17373-17382 (2017)
Evaluation and clinical significance of cyclin-dependent kinase5 expression in cervical lesions: a clinical research study in Guangxi, China
Pan DH, et al.
European Journal of Medical Research, 21(1), 28-28 (2016)
Cyclin-dependent kinase 5 controls vasculogenic mimicry formation in non-small cell lung cancer via the FAK-AKT signaling pathway
Zhou X, et al.
Biochemical and Biophysical Research Communications, 492(3), 447-452 (2017)
Chia-Yi Su et al.
Scientific reports, 9(1), 13703-13703 (2019-09-25)
Cyclin-dependent kinase 5 (Cdk5) is predominantly expressed in neuron and plays an important role in neuronal physiology. Increasing evidence also indicates that Cdk5 may contribute to malignant progression of some types of cancers; however, the underlying mechanism remains elusive. In
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