产品名称
抗-磷酸化-CDK5 (pTyr15) 兔抗, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 33 kDa
species reactivity
mouse, human, rat
concentration
~1 mg/mL
technique(s)
ELISA: 1:5000
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
phosphorylation (pTyr15)
Quality Level
Gene Information
human ... CDK5(1020)
Biochem/physiol Actions
Cyclin-dependent kinase 5 (CDK5) controls migration and neuronal plasticity. This protein participates in neuron migration, neurite outgrowth and support and synaptogenesis. It also helps in the development of lymphatic vessels. Suppressing Cdk5 promotes cell death of tumor-initiating cells.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
General description
Cyclin-dependent kinase 5 (CDK5) belongs to the CDKs family. Active CDK5 is present in pancreatic β cells, corneal epithelial cells and monocytes. This gene is mapped to human chromosome 7q36.
Immunogen
The antiserum was produced against synthesized peptide derived from human CDK5 around the phosphorylation site of Tyr15.
Immunogen Range: 1-50
Immunogen Range: 1-50
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Cyclin-dependent kinase 5 controls vasculogenic mimicry formation in non-small cell lung cancer via the FAK-AKT signaling pathway
Zhou X, et al.
Biochemical and Biophysical Research Communications, 492(3), 447-452 (2017)
Evaluation and clinical significance of cyclin-dependent kinase5 expression in cervical lesions: a clinical research study in Guangxi, China
Pan DH, et al.
European Journal of Medical Research, 21(1), 28-28 (2016)
Biological functions of CDK5 and potential CDK5 targeted clinical treatments
Shupp A, et al.
Oncotarget, 8(10), 17373-17382 (2017)
Inhibition of Cdk5 induces cell death of tumor-initiating cells
Mandl MM, et al.
British Journal of Cancer, 116(7), 912-922 (2017)
Kensei Taguchi et al.
The Journal of clinical investigation, 132(23) (2022-12-02)
Acute kidney injury (AKI) occurs in approximately 13% of hospitalized patients and predisposes patients to chronic kidney disease (CKD) through the AKI-to-CKD transition. Studies from our laboratory and others have demonstrated that maladaptive repair of proximal tubule cells (PTCs), including
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