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主要文件

安全信息

SAB4502896

Sigma-Aldrich

Anti-CD147, C-Terminal antibody produced in rabbit

affinity isolated antibody

别名:

BASI, CD147, basigin, basigin (Ok blood group), collagenase stimulatory factor

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About This Item

MDL编号:
UNSPSC代码:
12352203
NACRES:
NA.41

生物来源

rabbit

质量水平

偶联物

unconjugated

抗体形式

affinity isolated antibody

抗体产品类型

primary antibodies

克隆

polyclonal

表单

buffered aqueous solution

分子量

antigen 42 kDa

种属反应性

mouse, human, rat

浓度

~1 mg/mL

技术

ELISA: 1:10000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI登记号

UniProt登记号

运输

wet ice

储存温度

−20°C

靶向翻译后修饰

unmodified

基因信息

human ... BSG(682)

相关类别

一般描述

Anti-CD147 Antibody detects endogenous levels of total CD147 protein.
Cluster of differentiation 147 (CD147) is a multifunctional trans-membrane glycoprotein and is a member of the immunoglobulin superfamily. It occurs in transmembrane and soluble forms. CD147 is also known as EMMPRIN or basigin (BSG). It is a 57 kDa glycoprotein with two extracellular Ig domains. CD147 is located on human chromosome 19p13.

免疫原

The antiserum was produced against synthesized peptide derived from human CD147.

Immunogen Range: 336-385

应用

Anti-CD147, C-Terminal antibody has been used in western blotting.

生化/生理作用

Cluster of differentiation 147 (CD147) is considered as an extracellular matrix metalloproteinase inducer. It participates in several physiological and pathological activities, mainly in tumor invasion and metastasis. CD147 helps in tumor cell-macrophage interactions and stimulates MMPs (matrix metalloproteinases) and vascular endothelial growth factor (VEGF).

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外形

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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储存分类代码

10 - Combustible liquids

WGK

nwg

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

常规特殊物品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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访问文档库

Simvastatin attenuated rat thoracic aorta remodeling by decreasing ROCK2?mediated CyPA secretion and CD147-ERK1/2-cyclin pathway.
Tang FC, et al.
Molecular Medicine Reports, 16(6), 8123-8129 (2017)
Cytoplasmic fragment of CD147 generated by regulated intramembrane proteolysis contributes to HCC by promoting autophagy.
Wu B, et al.
Cell Death and Differentiation, 8(7), e2925-e2925 (2017)
CD147 overexpression may serve as a promising diagnostic and prognostic marker for gastric cancer: evidence from original research and literature.
Hu C, et al.
Oncotarget, 8(19), 30888?30899-30888?30899 (2017)
CD147-induced cell proliferation is associated with Smad4 signal inhibition.
Qin H, et al.
Experimental Cell Research, 358(2), 279-289 (2017)
BGMUT: NCBI dbRBC database of allelic variations of genes encoding antigens of blood group systems.
Patnaik SK, et al.
Nucleic Acids Research, 40(D1), D1023-D1029 (2011)

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