推荐产品
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
形式
buffered aqueous solution
分子量
antigen 227 kDa
种属反应性
mouse, human, rat
浓度
~1 mg/mL
技术
ELISA: 1:20000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... SCN2A(6323)
一般描述
Anti-SODIUM CHANNEL-PAN Antibody detects endogenous levels of total SODIUM CHANNEL-PAN protein.
The SCN5A (sodium channel protein type 5 subunit α) gene is mapped to human chromosome 3p22.2. The encoded protein is known to be localized to cardiac cells.
免疫原
The antiserum was produced against synthesized peptide derived from human Sodium Channel.
Immunogen Range: 1466-1515
Immunogen Range: 1466-1515
生化/生理作用
SCN5A (sodium channel protein type 5 subunit α) is associated with the regulation of myocardial excitability as it conducts cardiac depolarization via inward Na+ current. Mutation in SCN5A causes retarded cardiac repolarization resulting in congenital long QT syndrome and also causes Brugada syndrome due to loss of gene function.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Electrophysiological characterization of a large set of novel variants in the SCN5A-gene: identification of novel LQTS3 and BrS mutations.
Ortiz-Bonnin B
Pfluegers Archiv, 468(8), 1375-1387 (2016)
Sirtuin 1 regulates cardiac electrical activity by deacetylating the cardiac sodium channel.
Vikram A
Nature Medicine, 23(3), 361-367 (2017)
C-terminal phosphorylation of NaV1.5 impairs FGF13-dependent regulation of channel inactivation.
Burel S
The Journal of Biological Chemistry, 292(42), 17431-17448 (2017)
A common genetic variant within SCN10A modulates cardiac SCN5A expression.
van den Boogaard M
The Journal of Clinical Investigation, 124(4), 1844-1852 (2014)
Shehla U Hridi et al.
Molecular and cellular neurosciences, 95, 71-78 (2019-02-10)
Interleukin 16 (IL-16) is a cytokine that is primarily associated with CD4+ T cell function, but also exists as a multi-domain PDZ protein expressed within cerebellar and hippocampal neurons. We have previously shown that lymphocyte-derived IL-16 is neuroprotective against excitotoxicity
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