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生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
形式
buffered aqueous solution
分子量
antigen 98 kDa
种属反应性
rat, mouse, human
浓度
~1 mg/mL
技术
ELISA: 1:5000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... PGR(5241)
一般描述
Anti-Progesterone receptor antibody detects endogenous levels of total progesterone receptor protein.
The progesterone receptor (PR) gene is mapped to human chromosome 11q22–23. The gene encodes for two isoforms, namely PR-A and PR-B, each of which is transcribed from a specific promoter region. The encoded receptor belongs to the family of steroid hormone receptors.
免疫原
The antiserum was produced against synthesized peptide derived from human Progesterone Receptor.
Immunogen Range: 261-310
Immunogen Range: 261-310
应用
Anti-Progesterone receptor antibody produced in rabbit has been used in western blotting and immunohistochemistry.
生化/生理作用
Progesterone receptor (PR) mediates the actions of progesterone which is essential to maintain pregnancy. PR is known to regulate the genes involved in the process of cell cycle, cell adhesion, invasion, differentiation, proliferation, inflammation, and apoptosis. PR expression might serve as a biomarker in axillary lymph node (ALN) metastasis. Abnormal expression of PR is observed in breast cancer.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
CCAAT/enhancer binding protein ? negatively regulates progesterone receptor expression in human glioblastoma cells.
Hansberg-Pastor V
Molecular and Cellular Endocrinology, 439, 317-327 (2017)
Rapid impact of progesterone on the neuronal growth cone.
Olbrich L.
Endocrinology, 154(10), 3784-3795 (2013)
Absent progesterone receptor expression in the lymph node metastases of ER-positive, HER2-negative breast cancer is associated with relapse on tamoxifen.
Snell CE
Journal of Clinical Pathology, 70(11), 954-960 (2017)
Akt regulates progesterone receptor B-dependent transcription and angiogenesis in endometrial cancer cells.
Lee II
Oncogene, 35(39), 5191-5201 (2016)
No association between the progesterone receptor gene polymorphism (+331G/a) and the risk of breast cancer: an updated meta-analysis.
Qi XL
BMC Medical Genetics, 18(1):123, 1-7 (2017)
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