SAB4501880
抗-KI67 兔抗
affinity isolated antibody
别名:
MKI67, 抗原 KI-67
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA
immunofluorescence
immunohistochemistry
immunofluorescence
immunohistochemistry
Species reactivity:
human
Citations:
14
Technique(s):
ELISA: 1:10000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
Uniprot accession no.:
产品名称
抗-KI67 兔抗, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 358 kDa
species reactivity
human
concentration
~1 mg/mL
technique(s)
ELISA: 1:10000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... MKI67(4288)
Application
在兔子中产生的抗 KI67，C-端抗体已被用于以下研究：
- 免疫组化。
- 免疫荧光染色
- 蛋白质印迹法
Biochem/physiol Actions
增殖标志物Ki-67（MKI67）是有丝分裂染色体外周的一部分，作为生物表面活性剂在核膜解体后维持单个有丝分裂染色体在细胞质中的分散。Ki-67是乳腺癌和前列腺癌的关键预后指标。该编码蛋白的表达与细胞增殖速率有关。除休眠细胞外（G (0），Ki-67 在细胞周期的所有活跃期（G（1）、S、G（2）和有丝分裂）表达。因此，这种蛋白质被认为是一种潜在的细胞增殖标志物。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
Features and Benefits
完全放心地试用我们的抗体。如果抗体在您的申请的研究中不起作用，我们将全额退款或安排替代抗体。了解更多。
General description
增殖标志物Ki-67（MKI67）由位于人染色体10的基因编码。该编码蛋白的特点是 N-末端的磷酸肽结合叉头相关（FHA）结构域和蛋白磷酸酶 1（PP1）结合位点 ，中间区域的 16 个串联重复序列，以及 C-末端的亮氨酸和精氨酸（LR）对。
Immunogen
针对人源 Ki67 的合成肽产生抗血清。
免疫原范围：3207-3256
免疫原范围：3207-3256
Physical form
兔 IgG 溶于磷酸盐缓冲盐水（不含 Mg2+ 和 Ca2+），pH7.4，150mM NaCl，0.02％ 叠氮化钠和 50％ 甘油中。
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存储类别
12 - Non Combustible Liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
L Bubendorf et al.
The Journal of pathology, 178(4), 437-441 (1996-04-01)
The clinical course of prostate cancer is highly variable and cannot satisfactorily be predicted by histological criteria alone. Both tumour cell proliferation and neuroendocrine differentiation have been suggested as additional prognostic parameters, neuroendocrine differentiation being considered to enhance tumour cell
Di Wu et al.
Medical science monitor : international medical journal of experimental and clinical research, 25, 6946-6954 (2019-12-21)
BACKGROUND High blood glucose levels in diabetes result in retinal angiogenesis, which is the key feature of diabetic retinopathy. This study aimed to investigate the effects of the CXCR4 antagonist, AMD3465, on human retinal vascular endothelial cells (hRVECs) [i]in vitro[/i].
Sara Cuylen et al.
Nature, 535(7611), 308-312 (2016-07-01)
Eukaryotic genomes are partitioned into chromosomes that form compact and spatially well-separated mechanical bodies during mitosis. This enables chromosomes to move independently of each other for segregation of precisely one copy of the genome to each of the nascent daughter
Chuangui Chen et al.
OncoTargets and therapy, 17, 113-128 (2024-02-22)
Chronic gastroesophageal reflux disease (GERD) causes the abnormal reflux of acid and bile salts, which would induce Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC). EGFR, as one of main components of the exosome, plays an important role in cancer progression.
T Scholzen et al.
Journal of cellular physiology, 182(3), 311-322 (2000-02-01)
The expression of the human Ki-67 protein is strictly associated with cell proliferation. During interphase, the antigen can be exclusively detected within the nucleus, whereas in mitosis most of the protein is relocated to the surface of the chromosomes. The
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