生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
形式
buffered aqueous solution
分子量
antigen 358 kDa
种属反应性
human
浓度
~1 mg/mL
技术
ELISA: 1:10000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... MKI67(4288)
一般描述
增殖标志物Ki-67(MKI67)由位于人染色体10的基因编码。该编码蛋白的特点是 N-末端的磷酸肽结合叉头相关(FHA)结构域和蛋白磷酸酶 1(PP1)结合位点 ,中间区域的 16 个串联重复序列,以及 C-末端的亮氨酸和精氨酸(LR)对。
免疫原
针对人源 Ki67 的合成肽产生抗血清。
免疫原范围:3207-3256
免疫原范围:3207-3256
应用
在兔子中产生的抗 KI67,C-端抗体已被用于以下研究:
- 免疫组化。
- 免疫荧光染色
- 蛋白质印迹法
生化/生理作用
增殖标志物Ki-67(MKI67)是有丝分裂染色体外周的一部分,作为生物表面活性剂在核膜解体后维持单个有丝分裂染色体在细胞质中的分散。Ki-67是乳腺癌和前列腺癌的关键预后指标。该编码蛋白的表达与细胞增殖速率有关。除休眠细胞外(G (0),Ki-67 在细胞周期的所有活跃期(G(1)、S、G(2)和有丝分裂)表达。因此,这种蛋白质被认为是一种潜在的细胞增殖标志物。
特点和优势
完全放心地试用我们的抗体。如果抗体在您的申请的研究中不起作用,我们将全额退款或安排替代抗体。了解更多。
外形
兔 IgG 溶于磷酸盐缓冲盐水(不含 Mg2+ 和 Ca2+),pH7.4,150mM NaCl,0.02% 叠氮化钠和 50% 甘油中。
免责声明
除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
The Journal of pathology, 178(4), 437-441 (1996-04-01)
The clinical course of prostate cancer is highly variable and cannot satisfactorily be predicted by histological criteria alone. Both tumour cell proliferation and neuroendocrine differentiation have been suggested as additional prognostic parameters, neuroendocrine differentiation being considered to enhance tumour cell
Medical science monitor : international medical journal of experimental and clinical research, 25, 6946-6954 (2019-12-21)
BACKGROUND High blood glucose levels in diabetes result in retinal angiogenesis, which is the key feature of diabetic retinopathy. This study aimed to investigate the effects of the CXCR4 antagonist, AMD3465, on human retinal vascular endothelial cells (hRVECs) [i]in vitro[/i].
Nature, 535(7611), 308-312 (2016-07-01)
Eukaryotic genomes are partitioned into chromosomes that form compact and spatially well-separated mechanical bodies during mitosis. This enables chromosomes to move independently of each other for segregation of precisely one copy of the genome to each of the nascent daughter
Breast cancer research and treatment, 139(2), 539-552 (2013-05-16)
The proliferation marker Ki-67 is one of the most controversially discussed parameters for treatment decisions in breast cancer patients. The purpose of this study was to evaluate the routine use and value of Ki-67 as a prognostic marker, and to
Frontiers in surgery, 8, 644859-644859 (2021-07-06)
Background: A major limitation in expanding the use of donation after circulatory death (DCD) livers in transplantation is the increased risk of graft failure secondary to ischemic cholangiopathy. Warm ischemia causes thrombosis and injury to the peribiliary vascular plexus (PVP)
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