生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
形式
buffered aqueous solution
分子量
antigen 399 kDa
种属反应性
human, mouse
浓度
~1 mg/mL
技术
ELISA: 1:20000
immunohistochemistry: 1:50-1:100
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... LAMA5(3911)
一般描述
Anti-LAMA5 Antibody detects endogenous levels of total LAMA5 protein. Laminin alpha5 (LAMA5) codes for the laminin α5 chain. It is mapped to human chromosome 20q13.2- q13.3. In human skin, LAMA5 is produced and liberated by dermal pericytes.
免疫原
The antiserum was produced against synthesized peptide derived from human LAMA5.
Immunogen Range: 2381-2430
Immunogen Range: 2381-2430
应用
Anti-LAMA5 antibody has been used in immunohistochemistry, immunocytochemistry and immunofluorescent staining.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunofluorescence (1 paper)
Immunofluorescence (1 paper)
生化/生理作用
Furthermore, studies in mice showed that Lama5 is involved in organogenesis and placental function during pregnancy. LAMA5 may play a role in regulating inter-individual variability in metabolic phenotypes in children. It induces skin regeneration both in vitro and in vivo.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
A role for pericytes as microenvironmental regulators of human skin tissue regeneration.
Paquet-Fifield S, et al.
The Journal of Clinical Investigation, 119(9), 2795-2806 (2009)
Common variants in the LAMA5 gene associate with fasting plasma glucose and serum triglyceride levels in a cohort of pre-and early pubertal children.
De Luca M, et al.
Journal of pediatric genetics, 1(4), 229-234 (2012)
Glícia Maria de Almeida et al.
Scientific reports, 5, 17860-17860 (2015-12-15)
Extracellular matrix (ECM) is known to play several important roles in vascular development, although the molecular mechanisms behind these remain largely unknown. RECK, a tumor suppressor downregulated in a wide variety of cancers, encodes a membrane-anchored matrix-metalloproteinase-regulator. Mice lacking functional
Jyoti Gautam et al.
Scientific reports, 6, 36450-36450 (2016-11-04)
Laminin, a major component of the basement membrane, plays an important role in blood brain barrier regulation. At the neurovascular unit, brain endothelial cells, astrocytes, and pericytes synthesize and deposit different laminin isoforms into the basement membrane. It has been
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
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