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安全信息

SAB4501255

Sigma-Aldrich

Anti-Anti-Laminin (LAMA1) antibody

rabbit polyclonal

别名:

LAMA, LAMA1, Laminin A chain, Laminin subunit α-1

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About This Item

UNSPSC代码:
12352203
NACRES:
NA.41

产品名称

Anti-LAMA1 antibody produced in rabbit, affinity isolated antibody

生物来源

rabbit

质量水平

偶联物

unconjugated

抗体形式

affinity isolated antibody

抗体产品类型

primary antibodies

克隆

polyclonal

表单

buffered aqueous solution

分子量

antigen 337 kDa

种属反应性

human

浓度

~1 mg/mL

技术

ELISA: 1:40000
immunofluorescence: 1:100-1:500

NCBI登记号

UniProt登记号

运输

wet ice

储存温度

−20°C

靶向翻译后修饰

unmodified

基因信息

human ... LAMA1(284217)

一般描述

Anti-LAMA1 Antibody detects endogenous levels of total LAMA1 protein.
Laminins are extracellular matrix proteins. The LAMA1 (laminin subunit α 1) gene is mapped to chromosome 18p11.

免疫原

The antiserum was produced against synthesized peptide derived from human LAMA1.

Immunogen Range: 2501-2550

应用

Anti-LAMA1, C-Terminal antibody has been used in western blotting.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)

生化/生理作用

LAMA1 (laminin subunit α 1) participates in several diseases like cancer, infections, inflammatory diseases and autoimmune disorders. Mutations in LAMA1 result in cerebellar dysplasia and cysts with and without retinal dystrophy. LAMA1 is also essential in the assembly of basement membrane and early growth of embryo.

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外形

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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储存分类代码

10 - Combustible liquids

WGK

nwg

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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分析证书(COA)

Lot/Batch Number

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访问文档库

Mutations in LAMA1 cause cerebellar dysplasia and cysts with and without retinal dystrophy
Aldinger KA, et al.
American Journal of Human Genetics, 95, 227-234 (2014)
Autoimmunity against laminins
Florea F, et al.
Clinical Immunology (Orlando, Fla.), 170, 39-52 (2016)
Vertebrate evolution by interspecific hybridisation--are we polyploid?
Spring J
Febs Letters, 400, 2-8 (1997)
?3 Chains of type V collagen regulate breast tumour growth via glypican-1
Huang G, et al.
Nature Communications, 8 (2017)
Guorui Huang et al.
Nature communications, 8, 14351-14351 (2017-01-20)
Pericellular α3(V) collagen can affect the functioning of cells, such as adipocytes and pancreatic β cells. Here we show that α3(V) chains are an abundant product of normal mammary gland basal cells, and that α3(V) ablation in a mouse mammary

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