产品名称
Anti-ADORA2B antibody produced in rabbit, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 36 kDa
species reactivity
human
concentration
~1 mg/mL
technique(s)
ELISA: 1:1000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... ADORA2B(136)
Biochem/physiol Actions
ADORA2B (adenosine A2b receptor) acts as a therapeutic target for cancer treatment. The tumor cells can use A2b receptor to induce tumor progression. ADORA2B controls immune cell activity. It plays a major role in the transcriptional induction and protein stability of protein period 2 (Per2).
Features and Benefits
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General description
Anti-ADORA2B Antibody detects endogenous levels of total ADORA2B protein.
ADORA2B (adenosine A2b receptor) is a G-protein coupled receptor. It is the most adenosine insensitive adenosine receptor. This gene is located on human chromosome 17p12-p11.2. Anti-ADORA2B Antibody detects endogenous levels of total ADORA2B protein.
ADORA2B (adenosine A2b receptor) is a G-protein coupled receptor. It is the most adenosine insensitive adenosine receptor. This gene is located on human chromosome 17p12-p11.2. Anti-ADORA2B Antibody detects endogenous levels of total ADORA2B protein.
Immunogen
The antiserum was produced against synthesized peptide derived from human ADORA2B.
Immunogen Range: 231-280
Immunogen Range: 231-280
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
CD73-Dependent Generation of Adenosine and Endothelial Adora2b Signaling Attenuate Diabetic Nephropathy.
Eunyoung T, et al.
Journal of the American Society of Nephrology, 25 (3), 547-563 (2014)
Adora2b-elicited Per2 stabilization promotes a HIF-dependent metabolic switch crucial for myocardial adaptation to ischemia.
Eckle T, et al.
Nature Medicine, 18(5), 774-774 (2012)
Pharmacogenetics of asthma.
Fenech A and Hall IP
British Journal of Clinical Pharmacology, 53(1), 3-15 (2002)
Role of adenosine A2b receptor overexpression in tumor progression.
Sepulveda C, et al.
Life Sciences, 166, 92-99 (2016)
The A2b adenosine receptor antagonist PSB-603 promotes oxidative phosphorylation and ROS production in colorectal cancer cells via adenosine receptor-independent mechanism.
M?lck C, et al.
Cancer Letters, 383(1), 135-143 (2016)
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