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生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
形式
buffered aqueous solution
分子量
antigen 129 kDa
种属反应性
human
浓度
~1 mg/mL
技术
ELISA: 1:20000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... COL1A2(1278)
一般描述
Anti-Collagen I α2 Antibody detects endogenous levels of total Collagen I α2 protein.
Collagen I α2 (COL1A2) is located on human chromosome 7q22.1. Human COL1A2 gene consists of two dinucleotide repeats: one in the 5′-flanking region of the gene, made of of poly(dC–dA) and poly(dC–dG) and the other in the first intron comprised of poly(dG–dT).
免疫原
The antiserum was produced against synthesized peptide derived from human Collagen I alpha2.
Immunogen Range: 471-520
Immunogen Range: 471-520
应用
Anti-Collagen I α2 antibody has been used to quantify protein expression levels after western blotting.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)
Immunohistochemistry (1 paper)
生化/生理作用
Collagen I α2 (COL1A2) is essential to maintain elasticity of the vessel wall and is an important constituent of the extracellular matrix. Mutations in COL1A2 results in osteogenesis imperfecta (OI).
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Jianhui Xu et al.
Proteomics. Clinical applications, 14(4), e1900112-e1900112 (2020-03-12)
Cystic vestibular schwannoma (CVS) and solid vestibular schwannoma (SVS) are subgroups of vestibular schwannoma (VS). The tumorigenesis of CVS and SVS have not been fully elucidated, and this study is designed to identify differentially expressed proteins involved in the tumorigenesis
Collagen type I ?2 (COL1A2) is the susceptible gene for intracranial aneurysms.
Yoneyama T, et al.
Stroke, 35(2), 443-448 (2004)
Mutation in a gene for type I procollagen (COL1A2) in a woman with postmenopausal osteoporosis: evidence for phenotypic and genotypic overlap with mild osteogenesis imperfecta.
Spotila LD, et al.
Proceedings of the National Academy of Sciences of the USA, 88(12), 5423-5427 (1991)
Influence of COL1A2 gene variants on the incidence of hypertensive intracerebral hemorrhage in a Chinese population.
Tian DZ, et al.
Genetics and molecular research : GMR, 15(1) (2015)
Transcriptional regulation of the human type I collagen ?2 (COL1A2) gene by the combination of two dinucleotide repeats.
Akai J, et al.
Gene, 239(1), 65-73 (1999)
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