产品名称
抗 p16 油墨 兔抗, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 16 kDa
species reactivity
mouse, human
concentration
~1 mg/mL
technique(s)
ELISA: 1:5000
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... CDKN2A(1029)
Application
兔生产的抗p16 INK N末端抗体可用于蛋白质印迹分析。
Biochem/physiol Actions
细胞周期素依赖性激酶抑制剂2A(CDKN2A)也称P16-INK4A,它通过抑制S期阻止细胞周期进程,并促进细胞凋亡。该编码蛋白具有抗增殖生物活性,并与视网膜母细胞瘤(Rb)蛋白通路有关。P16-INK4A是一种肿瘤抑制剂,在老化和细胞衰老中起着至关重要的作用。该蛋白表达的增加可能导致各种高级别癌症(high grade cance)。 P16-INK4A 也促进细胞侵袭和血管生成。支气管灌洗P16INK4A促进剂的甲基化可作为肺癌诊断的潜在生物标志物。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
Features and Benefits
完全放心地试用我们的抗体。如果抗体在您的申请的研究中不起作用,我们将全额退款或安排替代抗体。了解更多。
General description
抗 p16 INK 抗体可检测内源性 p16 INK 总蛋白水平。
细胞周期素依赖性激酶抑制剂2A(CDKN2A)也称P16-INK4A,属于CDK抑制剂Ink4(CDK4抑制剂)家族。由位于人类染色体9p21上在INK4a/可选读码框(ARF)位点内的基因编码。人P16-INK4A在细胞核与细胞质中均有分布,在皮肤和肾脏组织中的表达随着年龄的增加而上升。
Immunogen
针对人源 p16 INK的合成肽产生抗血清。
免疫原范围:10-59
免疫原范围:10-59
Physical form
兔 IgG 溶于磷酸盐缓冲盐水(不含 Mg2+ 和 Ca2+),pH7.4,150mM NaCl,0.02% 叠氮化钠和 50% 甘油中。
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
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