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生物来源
rabbit
质量水平
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
90 kDa
种属反应性
human
浓度
1.0 mg/mL
技术
western blot: 1:500-1:1000 (Cell Lysate)
同位素/亚型
IgG
登记号
NP_002002.3.
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
phosphorylation (pTyr642)
基因信息
human ... FGFR4(2264)
一般描述
Fibroblast growth factor receptor 4 (FGFR4) protein is a tyrosine kinase (TK) receptor comprising an extracellular domain, a transmembrane domain, and an intracellular domain. FGFR4 is expressed in the adrenal cortex, bile duct, cervix, cornea, heart, hepatocyte, intestine, kidney, liver, lung, lymph node, mammary gland, muscle, ovary, pituitary gland, renal tubular epithelium, retina, skin, spleen, stomach, ureter, urothelium, and uterus. FGFR4 gene is located on human chromosome 5q35.2.
特异性
The antibody detects endogenous levels of FGFR4 only when phosphorylated at tyrosine 642.
免疫原
Peptide sequence around phosphorylation site of tyrosine 642(I-D-Y(p)-Y-K) derived from Human FGFR4 .
生化/生理作用
Fibroblast growth factor receptor 4 (FGFR4) protein possesses tyrosine-protein kinase activity and serves as a cell-surface receptor for fibroblast growth factors. It regulates cell proliferation, differentiation, and migration. FGFR4 also participates in survival during embryonic development. It helps with tissue homeostasis, tissue repair, angiogenesis, and inflammation in adults. FGFR4 is expressed at a high level in various cancer types. It plays a key role in tumor subtype differentiation in luminal breast cancer and metastatic disease. Oncogenic mutations of the FGFR4 gene are associated with rhabdomyosarcoma (RMS) and primary gastric cancer.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
FGFR4 (fibroblast growth factor receptor 4)
Pelaez-Garcia A, et al.
Atlas of Genetics and Cytogenetics in Oncology and Haematology (2012)
Susana Garcia-Recio et al.
The Journal of clinical investigation, 130(9), 4871-4887 (2020-06-24)
Mechanisms driving tumor progression from less aggressive subtypes to more aggressive states represent key targets for therapy. We identified a subset of luminal A primary breast tumors that give rise to HER2-enriched (HER2E) subtype metastases, but remain clinically HER2 negative
Takashi Futami et al.
Scientific reports, 9(1), 14627-14627 (2019-10-12)
Gastric cancer remains one of the leading causes of cancer death worldwide. Despite intensive investigations of treatments over the past three decades, the poor prognosis of patients with unresectable advanced or recurrent gastric cancer has not significantly changed, and improved
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