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生物来源
rabbit
质量水平
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
形式
buffered aqueous solution
分子量
21 kDa
种属反应性
mouse, rat, human
浓度
0.7 mg/mL
技术
western blot: 1:200-1:1000 (Cell Lysate)
同位素/亚型
IgG
登记号
NP_001123914.1
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... HRAS(3265)
一般描述
Ras is a proto-oncogene and the gene encoding it is localized on human chromosome 11p15.5. It is a 21 kDa protein and is part of the small GTP-binding proteins superfamily.
特异性
The antibody detects endogenous level of total RAS protein.
免疫原
Synthetic peptide corresponding to a region derived from 60-74 amino acids of Human v-Ha-ras Harvey rat sarcoma viral oncogene homolog
生化/生理作用
Ras is a guanine-nucleotide binding protein that couples tyrosine kinase receptor signals to mitogen activated protein (MAP) kinase cascade. It has an important role in cell growth. Ras is a substrate for farnesyltransferase (FTase) and when farnesylated, it is anchored to the membrane. Membrane localization of Ras is crucial for its cellular activity. Inhibition of Ras farnesylation is a target for anti-cancer drug development.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
Supplied at 0.7mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.3, 0.05% sodium azide and 50% glycerol.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Germline mutations in HRAS proto-oncogene cause Costello syndrome.
Aoki Y, et al.
Nature Genetics, 37(10), 1038-1038 (2005)
Human mucin gene MUC5B, the 10.7-kb large central exon encodes various alternate subdomains resulting in a super-repeat structural evidence for a 11p15. 5 gene family.
Desseyn J L, et al.
The Journal of Biological Chemistry, 272(6), 3168-3178 (1997)
Ras protein farnesyltransferase: A strategic target for anticancer therapeutic development.
Rowinsky E K, et al.
Journal of Clinical Oncology, 7(11), 3631-3652 (1999)
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